Rhesus Recombinant IL17RB protein, ECD, His Tag (V2LY-0526-LY9742)

Name: Rhesus Recombinant IL17RB protein, ECD, His Tag
SKU: V2LY-0526-LY9742
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Rhesus

Tag

His Tag

Protein Construction

This product is Rhesus Recombinant IL17RB protein, ECD, His Tag consist of Amino Acid: 1-288 and predicts a molecular mass of 31.4 kDa.

Molecule Mass

31.4 kDa

Protein Domain

ECD

Sequence

Amino Acid: 1-288

Species

Rhesus

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 17 Receptor B

Function

Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.

Biological Process

Defense response Source: ProtInc
Regulation of cell growth Source: UniProtKB

Cellular Location

Isoform 1: Cell membrane
Isoform 2: Secreted

Topology

Extracellular: 18-292
Helical: 293-313
Cytoplasmic: 314-502

Yuan, S. S. F., Su, C. W., Chan, L. P., Nguyen, H. D., Chen, Y. K., Du, J. K., ... & Wang, Y. Y. (2023). IL17RB expression is associated with malignant cancer behaviors and poor prognosis in oral cancer. Oral Diseases.

Sun, Y., Khan, M. A. A. K., Mangiola, S., & Barrow, A. D. (2023). IL17RB and IL17REL Expression Are Associated with Improved Prognosis in HPV-Infected Head and Neck Squamous Cell Carcinomas. Pathogens, 12(4), 572.

Boyraz, B., Kirkpatrick, G., Kaluziak, S. T., Morris, R., Kreuzer, J., Haas, W., ... & Sgroi, D. (2023). Abstract P2-03-05: HOXB13/IL17RB-low breast cancers are predicted to respond to PIK3CA inhibitors independent of PIK3CA mutational status. Cancer Research, 83(5_Supplement), P2-03.

Bing, N., Zhou, H., Chen, X., Hirose, T., Kochi, Y., Tsuchida, Y., ... & Clark, J. D. (2021). Contribution of a european‐prevalent variant near CD83 and an east asian–prevalent variant near IL17RB to herpes zoster risk in tofacitinib treatment: results of genome‐wide association study meta‐analyses. Arthritis & rheumatology, 73(7), 1155-1166.

Todorović-Raković, N., Milovanović, J., Greenman, J., & Radulovic, M. (2021). The significance of HOXB7 and IL17RB serum levels in prognosis of hormonally dependent breast cancer: A pilot study. Advances in Medical Sciences, 66(2), 359-365.

Hu, O., Provvido, A., & Zhu, Y. (2020). Generation of IL17RB Knockout Cell Lines Using CRISPR/Cas9-Based Genome Editing. Immune Mediators in Cancer: Methods and Protocols, 345-353.

Song, Y., Ji, B., Jiang, C. X., Chen, Z. M., Yao, N. H., Mukaida, N., & Huang, H. (2019). IL17RB expression might predict prognosis and benefit from gemcitabine in patients with resectable pancreatic cancer. Pathology-Research and Practice, 215(12), 152650.

Goto, N., Fukuda, A., Yamaga, Y., Yoshikawa, T., Maruno, T., Maekawa, H., ... & Seno, H. (2019). Lineage tracing and targeting of IL17RB+ tuft cell-like human colorectal cancer stem cells. Proceedings of the National Academy of Sciences, 116(26), 12996-13005.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant IL17RB protein, hFc Tag (CAT#: V2LY-0526-LY4782)

Human Recombinant IL17RB protein, His Tag (CAT#: V2LY-0526-LY4783)

Mouse Recombinant IL17RB protein, hFc Tag (CAT#: V2LY-0526-LY8495)

Mouse Recombinant IL17RB protein, His Tag (CAT#: V2LY-0526-LY8496)

Rhesus Recombinant IL17RB protein, hFc Tag (CAT#: V2LY-0526-LY9743)

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Mouse Recombinant IL17RB protein, hFc Tag (CAT#: V2LY-0526-LY8495)

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Rhesus Recombinant IL17RB protein, hFc Tag (CAT#: V2LY-0526-LY9743)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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