Rat Anti-IL20RB Recombinant Antibody (20RNTC) (CBMAB-I0489-YY)

Name: Rat Anti-IL20RB Recombinant Antibody (20RNTC)
SKU: CBMAB-I0489-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

20RNTC

Application

FC, ICC, IF, WB

Specificity

Human, Mouse

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Preservative

0.09% sodium azide

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

interleukin 20 receptor subunit beta

Introduction

IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619)

Entrez Gene ID

Human	53833
Mouse	213208

UniProt ID

Human	Q6UXL0
Mouse	Q3UVG8

Alternative Names

Interleukin 20 Receptor Subunit Beta

Function

The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.

Biological Process

Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Homeostasis of number of cells within a tissueIEA:Ensembl
Immune response-inhibiting signal transductionIEA:Ensembl
Inflammatory response to antigenic stimulusIEA:Ensembl
Negative regulation of interferon-gamma productionIEA:Ensembl
Negative regulation of interleukin-2 productionIEA:Ensembl
Negative regulation of T cell proliferationIEA:Ensembl
Negative regulation of type IV hypersensitivityIEA:Ensembl
Positive regulation of interleukin-10 productionIEA:Ensembl
Positive regulation of interleukin-4 productionIEA:Ensembl

Cellular Location

Membrane

Topology

Extracellular: 30-233
Helical: 234-254
Cytoplasmic: 255-311

Guo, H., Jiang, S., Sun, H., Shi, B., Li, Y., Zhou, N., ... & Guo, H. (2022). Identification of IL20RB as a novel prognostic and therapeutic biomarker in clear cell renal cell carcinoma. Disease Markers, 2022.

Zhang, H., Liu, Y., Wang, B., & Wang, C. (2022). Interleukin 20 receptor subunit beta (IL20RB) predicts poor prognosis and regulates immune cell infiltration in clear cell renal cell carcinoma. BMC Genomic Data, 23(1), 1-14.

Kong, L., Jiang, D., He, C., Xia, J., Wei, H., Zhou, L., & Peng, H. (2020). TgROP18 targets IL20RB for host-defense-related-STAT3 activation during Toxoplasma gondii infection. Parasites & Vectors, 13(1), 1-14.

Kong, L., Jiang, D., He, C., Xia, J., We, H., Zhou, L., & Peng, H. J. (2020). TgROP18 Targets IL20RB for Host-Defense-Related-STAT3 Activation During T. gondii Infection.

Cui, X. F., Cui, X. G., & Leng, N. (2019). Overexpression of interleukin-20 receptor subunit beta (IL20RB) correlates with cell proliferation, invasion and migration enhancement and poor prognosis in papillary renal cell carcinoma. Journal of Toxicologic Pathology, 32(4), 245-251.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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