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Mouse Anti-IL22 Recombinant Antibody (A536) (CBMAB-AP3771LY)

The product is antibody recognizes IL22. The antibody A536 immunoassay techniques such as: ELISA, FC, WB.
See all IL22 antibodies

Summary

Host Animal
Mouse
Specificity
Fish
Clone
A536
Antibody Isotype
IgG1, κ
Application
ELISA, FC, WB

Basic Information

Immunogen
Ovalbumin-conjugated synthetic peptide sequence located within the central region of the mature IL-22 polypeptide
Specificity
Fish
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
interleukin 22
Entrez Gene ID
553964
UniProt ID
Q5TLE4
Alternative Names
Cytokine Zcyto18, IL 10 related T cell derived inducible factor, IL 21, IL 22, IL D110, IL TIF, IL-10-related T-cell-derived-inducible factor, IL-22, IL-TIF, IL21, Il22, ILD110, ILTIF
Function
Cytokine that contributes to the inflammatory response in vivo.
Biological Process
Acute-phase response1 PublicationNAS:UniProtKB
Inflammatory response1 PublicationNAS:UniProtKB
Response to glucocorticoidIEA:Ensembl
Cellular Location
Secreted

Han, H., Davidson, L. A., Fan, Y. Y., Landrock, K. K., Jayaraman, A., Safe, S. H., & Chapkin, R. S. (2022). Loss of aryl hydrocarbon receptor suppresses the response of colonic epithelial cells to IL22 signaling by upregulating SOCS3. American Journal of Physiology-Gastrointestinal and Liver Physiology, 322(1), G93-G106.

Ghimire, S., Ederer, K. U., Meedt, E., Weber, D., Matos, C., Hiergeist, A., ... & Bülow, S. (2022). Low intestinal IL22 associates with increased transplant-related mortality after allogeneic stem cell transplantation. Frontiers in immunology, 13, 857400.

Kumar, A., Patel, V. S., Harding, J. N., You, D., & Cormier, S. A. (2021). Exposure to combustion derived particulate matter exacerbates influenza infection in neonatal mice by inhibiting IL22 production. Particle and fibre toxicology, 18(1), 1-11.

Shaler, C. R., Parco, A. A., Elhenawy, W., Dourka, J., Jury, J., Verdu, E. F., & Coombes, B. K. (2021). Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts. Nature Communications, 12(1), 6664.

Zou, J., Reddivari, L., Shi, Z., Li, S., Wang, Y., Bretin, A., ... & Gewirtz, A. T. (2021). Inulin fermentable fiber ameliorates type I diabetes via IL22 and short-chain fatty acids in experimental models. Cellular and molecular gastroenterology and hepatology, 12(3), 983-1000.

Cheng, B., Rong, A., Zhou, Q., & Li, W. (2020). LncRNA LINC00662 promotes colon cancer tumor growth and metastasis by competitively binding with miR-340-5p to regulate CLDN8/IL22 co-expression and activating ERK signaling pathway. Journal of Experimental & Clinical Cancer Research, 39(1), 1-21.

Li, Z., Liang, X., Liu, W., Zhao, Y., Yang, H., Li, W., ... & Martyniuk, C. J. (2020). Elucidating mechanisms of immunotoxicity by benzotriazole ultraviolet stabilizers in zebrafish (Danio rerio): Implication of the AHR-IL17/IL22 immune pathway. Environmental Pollution, 262, 114291.

Zwarycz, B., Gracz, A. D., Rivera, K. R., Williamson, I. A., Samsa, L. A., Starmer, J., ... & Magness, S. T. (2019). IL22 inhibits epithelial stem cell expansion in an ileal organoid model. Cellular and molecular gastroenterology and hepatology, 7(1), 1-17.

Pollock, R. A., Zaman, L., Chandran, V., & Gladman, D. D. (2019). Epigenome-wide analysis of sperm cells identifies IL22 as a possible germ line risk locus for psoriatic arthritis. PLoS One, 14(2), e0212043.

Khosravi, N., Caetano, M. S., Cumpian, A. M., Unver, N., De la Garza Ramos, C., Noble, O., ... & Moghaddam, S. J. (2018). IL22 promotes kras-mutant lung cancer by induction of a protumor immune response and protection of stemness properties. Cancer immunology research, 6(7), 788-797.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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