Human Recombinant IL22 protein (V2LY-0526-LY4841)

Name: Human Recombinant IL22 protein
SKU: V2LY-0526-LY4841
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Protein Construction

This product is Human Recombinant IL22 protein consist of Amino Acid: 34-179 and predicts a molecular mass of 16.9 kDa.

Molecule Mass

16.9 kDa

Verified

MALS

Sequence

Amino Acid: 34-179

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥95% as determined by SEC-MALS.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Sodium citrate buffer

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

interleukin 22

Function

Cytokine that contributes to the inflammatory response in vivo.

Biological Process

Acute-phase response1 PublicationNAS:UniProtKB
Inflammatory response1 PublicationNAS:UniProtKB
Response to glucocorticoidIEA:Ensembl

Cellular Location

Secreted

Han, H., Davidson, L. A., Fan, Y. Y., Landrock, K. K., Jayaraman, A., Safe, S. H., & Chapkin, R. S. (2022). Loss of aryl hydrocarbon receptor suppresses the response of colonic epithelial cells to IL22 signaling by upregulating SOCS3. American Journal of Physiology-Gastrointestinal and Liver Physiology, 322(1), G93-G106.

Ghimire, S., Ederer, K. U., Meedt, E., Weber, D., Matos, C., Hiergeist, A., ... & Bülow, S. (2022). Low intestinal IL22 associates with increased transplant-related mortality after allogeneic stem cell transplantation. Frontiers in immunology, 13, 857400.

Kumar, A., Patel, V. S., Harding, J. N., You, D., & Cormier, S. A. (2021). Exposure to combustion derived particulate matter exacerbates influenza infection in neonatal mice by inhibiting IL22 production. Particle and fibre toxicology, 18(1), 1-11.

Shaler, C. R., Parco, A. A., Elhenawy, W., Dourka, J., Jury, J., Verdu, E. F., & Coombes, B. K. (2021). Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts. Nature Communications, 12(1), 6664.

Zou, J., Reddivari, L., Shi, Z., Li, S., Wang, Y., Bretin, A., ... & Gewirtz, A. T. (2021). Inulin fermentable fiber ameliorates type I diabetes via IL22 and short-chain fatty acids in experimental models. Cellular and molecular gastroenterology and hepatology, 12(3), 983-1000.

Cheng, B., Rong, A., Zhou, Q., & Li, W. (2020). LncRNA LINC00662 promotes colon cancer tumor growth and metastasis by competitively binding with miR-340-5p to regulate CLDN8/IL22 co-expression and activating ERK signaling pathway. Journal of Experimental & Clinical Cancer Research, 39(1), 1-21.

Li, Z., Liang, X., Liu, W., Zhao, Y., Yang, H., Li, W., ... & Martyniuk, C. J. (2020). Elucidating mechanisms of immunotoxicity by benzotriazole ultraviolet stabilizers in zebrafish (Danio rerio): Implication of the AHR-IL17/IL22 immune pathway. Environmental Pollution, 262, 114291.

Zwarycz, B., Gracz, A. D., Rivera, K. R., Williamson, I. A., Samsa, L. A., Starmer, J., ... & Magness, S. T. (2019). IL22 inhibits epithelial stem cell expansion in an ileal organoid model. Cellular and molecular gastroenterology and hepatology, 7(1), 1-17.

Pollock, R. A., Zaman, L., Chandran, V., & Gladman, D. D. (2019). Epigenome-wide analysis of sperm cells identifies IL22 as a possible germ line risk locus for psoriatic arthritis. PLoS One, 14(2), e0212043.

Khosravi, N., Caetano, M. S., Cumpian, A. M., Unver, N., De la Garza Ramos, C., Noble, O., ... & Moghaddam, S. J. (2018). IL22 promotes kras-mutant lung cancer by induction of a protumor immune response and protection of stemness properties. Cancer immunology research, 6(7), 788-797.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-IL22 Recombinant Antibody (CAT#: CBMAB-BR305LY)

Human Recombinant IL22 protein, His Tag (CAT#: V2LY-0526-LY4840)

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Human Recombinant IL22 protein, His Tag (CAT#: V2LY-0526-LY4840)

Mouse Anti-IL22 Recombinant Antibody (CAT#: CBMAB-BR305LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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