Mouse Anti-IL22 Recombinant Antibody (CBYY-I0186) (CBMAB-I0506-YY)

Name: Mouse Anti-IL22 Recombinant Antibody (CBYY-I0186)
SKU: CBMAB-I0506-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-I0186

Application

ICFC

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2, 0.2% (w/v) BSA

Preservative

0.09% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

interleukin 22

Introduction

IL22 (Interleukin 22) is a Protein Coding gene. Diseases associated with IL22 include Scleritis and Acute Generalized Exanthematous Pustulosis. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system.

Entrez Gene ID

50616

UniProt ID

Q9GZX6

Alternative Names

Interleukin 22

Function

Cytokine that contributes to the inflammatory response in vivo.

Biological Process

Acute-phase response1 PublicationNAS:UniProtKB
Inflammatory response1 PublicationNAS:UniProtKB
Response to glucocorticoidIEA:Ensembl

Cellular Location

Secreted

Han, H., Davidson, L. A., Fan, Y. Y., Landrock, K. K., Jayaraman, A., Safe, S. H., & Chapkin, R. S. (2022). Loss of aryl hydrocarbon receptor suppresses the response of colonic epithelial cells to IL22 signaling by upregulating SOCS3. American Journal of Physiology-Gastrointestinal and Liver Physiology, 322(1), G93-G106.

Ghimire, S., Ederer, K. U., Meedt, E., Weber, D., Matos, C., Hiergeist, A., ... & Bülow, S. (2022). Low intestinal IL22 associates with increased transplant-related mortality after allogeneic stem cell transplantation. Frontiers in immunology, 13, 857400.

Kumar, A., Patel, V. S., Harding, J. N., You, D., & Cormier, S. A. (2021). Exposure to combustion derived particulate matter exacerbates influenza infection in neonatal mice by inhibiting IL22 production. Particle and fibre toxicology, 18(1), 1-11.

Shaler, C. R., Parco, A. A., Elhenawy, W., Dourka, J., Jury, J., Verdu, E. F., & Coombes, B. K. (2021). Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts. Nature Communications, 12(1), 6664.

Zou, J., Reddivari, L., Shi, Z., Li, S., Wang, Y., Bretin, A., ... & Gewirtz, A. T. (2021). Inulin fermentable fiber ameliorates type I diabetes via IL22 and short-chain fatty acids in experimental models. Cellular and molecular gastroenterology and hepatology, 12(3), 983-1000.

Cheng, B., Rong, A., Zhou, Q., & Li, W. (2020). LncRNA LINC00662 promotes colon cancer tumor growth and metastasis by competitively binding with miR-340-5p to regulate CLDN8/IL22 co-expression and activating ERK signaling pathway. Journal of Experimental & Clinical Cancer Research, 39(1), 1-21.

Li, Z., Liang, X., Liu, W., Zhao, Y., Yang, H., Li, W., ... & Martyniuk, C. J. (2020). Elucidating mechanisms of immunotoxicity by benzotriazole ultraviolet stabilizers in zebrafish (Danio rerio): Implication of the AHR-IL17/IL22 immune pathway. Environmental Pollution, 262, 114291.

Zwarycz, B., Gracz, A. D., Rivera, K. R., Williamson, I. A., Samsa, L. A., Starmer, J., ... & Magness, S. T. (2019). IL22 inhibits epithelial stem cell expansion in an ileal organoid model. Cellular and molecular gastroenterology and hepatology, 7(1), 1-17.

Pollock, R. A., Zaman, L., Chandran, V., & Gladman, D. D. (2019). Epigenome-wide analysis of sperm cells identifies IL22 as a possible germ line risk locus for psoriatic arthritis. PLoS One, 14(2), e0212043.

Khosravi, N., Caetano, M. S., Cumpian, A. M., Unver, N., De la Garza Ramos, C., Noble, O., ... & Moghaddam, S. J. (2018). IL22 promotes kras-mutant lung cancer by induction of a protumor immune response and protection of stemness properties. Cancer immunology research, 6(7), 788-797.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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