Rat Anti-IL3 Recombinant Antibody (CBYY-I0649) (CBMAB-I1462-YY)

Name: Rat Anti-IL3 Recombinant Antibody (CBYY-I0649)
SKU: CBMAB-I1462-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBYY-I0649

Application

ELISA, FC, IF

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

100 mM BBS, pH 8.0

Concentration

0.5 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Interleukin 3

Introduction

The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.

Entrez Gene ID

3562

UniProt ID

P08700

Alternative Names

Interleukin 3

Function

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.
This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.

Biological Process

Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Embryonic hemopoiesisManual Assertion Based On ExperimentIDA:DFLAT
Immune responseIEA:InterPro
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylationISS:UniProtKB
Positive regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

Secreted

Wang, H., Tumes, D. J., Hercus, T. R., Yip, K. H., Aloe, C., Vlahos, R., ... & Bozinovski, S. (2022). Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models. Cell Death & Disease, 13(2), 137.

Rani, L., Kumar, A., Karhade, J., Pandey, G., Guha, A., Mishra, G. C., & Wani, M. R. (2022). IL‐3 regulates the differentiation of pathogenic Th17 cells. European Journal of Immunology, 52(11), 1842-1858.

Varricchi, G., Poto, R., Marone, G., & Schroeder, J. T. (2021, April). IL-3 in the development and function of basophils. In Seminars in immunology (Vol. 54, p. 101510). Academic Press.

Aldoss, I., Clark, M., Song, J. Y., & Pullarkat, V. (2020). Targeting the alpha subunit of IL-3 receptor (CD123) in patients with acute leukemia. Human vaccines & immunotherapeutics, 16(10), 2341-2348.

Tong, Y., Lear, T. B., Evankovich, J., Chen, Y., Londino, J. D., Myerburg, M. M., ... & Chen, B. B. (2020). The RNFT2/IL-3Rα axis regulates IL-3 signaling and innate immunity. JCI insight, 5(3).

Kumar, A., Rani, L., Mhaske, S. T., Pote, S. T., Behera, S., Mishra, G. C., & Wani, M. R. (2020). IL-3 receptor expression on activated human Th cells is regulated by IL-4, and IL-3 synergizes with IL-4 to enhance Th2 cell differentiation. The Journal of Immunology, 204(4), 819-831.

Dougan, M., Dranoff, G., & Dougan, S. K. (2019). GM-CSF, IL-3, and IL-5 family of cytokines: regulators of inflammation. Immunity, 50(4), 796-811.

Borriello, F., Galdiero, M. R., Varricchi, G., Loffredo, S., Spadaro, G., & Marone, G. (2019). Innate immune modulation by GM-CSF and IL-3 in health and disease. International journal of molecular sciences, 20(4), 834.

Zaidi, N., Quezada, S. A., Kuroiwa, J. M., Zhang, L., Jaffee, E. M., Steinman, R. M., & Wang, B. (2019). Anti–CTLA‐4 synergizes with dendritic cell–targeted vaccine to promote IL‐3–dependent CD4+ effector T cell infiltration into murine pancreatic tumors. Annals of the New York Academy of Sciences, 1445(1), 62-73.

Broughton, S. E., Hercus, T. R., Nero, T. L., Kan, W. L., Barry, E. F., Dottore, M., ... & Parker, M. W. (2018). A dual role for the N-terminal domain of the IL-3 receptor in cell signalling. Nature communications, 9(1), 386.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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