Mouse Anti-IL31 Recombinant Antibody (A551) (CBMAB-AP10885LY)

Name: Mouse Anti-IL31 Recombinant Antibody (A551)
SKU: CBMAB-AP10885LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A551

Application

Immunogen

Recombinant protein of human IL31

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Interleukin 31

Introduction

IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008]

Entrez Gene ID

386653

UniProt ID

Q6EBC2

Alternative Names

Interleukin 31

Function

A11476

Biological Process

Immune system processIEA:UniProtKB-KW

Cellular Location

Secreted

Borgia, F., Custurone, P., Li Pomi, F., Cordiano, R., Alessandrello, C., & Gangemi, S. (2022). IL-31: State of the art for an inflammation-oriented interleukin. International Journal of Molecular Sciences, 23(12), 6507.

Dubin, C., Del Duca, E., & Guttman-Yassky, E. (2021). The IL-4, IL-13 and IL-31 pathways in atopic dermatitis. Expert Review of Clinical Immunology, 17(8), 835-852.

Kunimura, K., & Fukui, Y. (2021). The molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development. International immunology, 33(12), 731-736.

De Martinis, M., Sirufo, M. M., Suppa, M., & Ginaldi, L. (2020). IL-33/IL-31 axis in osteoporosis. International journal of molecular sciences, 21(4), 1239.

Topal, F. A., Zuberbier, T., Makris, M. P., & Hofmann, M. (2020). The role of IL-17, IL-23 and IL-31, IL-33 in allergic skin diseases. Current opinion in allergy and clinical immunology, 20(4), 367-373.

Murdaca, G., Greco, M., Tonacci, A., Negrini, S., Borro, M., Puppo, F., & Gangemi, S. (2019). IL-33/IL-31 axis in immune-mediated and allergic diseases. International journal of molecular sciences, 20(23), 5856.

Miake, S., Tsuji, G., Takemura, M., Hashimoto-Hachiya, A., Vu, Y. H., Furue, M., & Nakahara, T. (2019). IL-4 augments IL-31/IL-31 receptor alpha interaction leading to enhanced Ccl 17 and Ccl 22 production in dendritic cells: implications for atopic dermatitis. International journal of molecular sciences, 20(16), 4053.

Bağci, I. S., & Ruzicka, T. (2018). IL-31: a new key player in dermatology and beyond. Journal of Allergy and Clinical Immunology, 141(3), 858-866.

Di Salvo, E., Ventura-Spagnolo, E., Casciaro, M., Navarra, M., & Gangemi, S. (2018). IL-33/IL-31 axis: a potential inflammatory pathway. Mediators of inflammation, 2018.

Takamori, A., Nambu, A., Sato, K., Yamaguchi, S., Matsuda, K., Numata, T., ... & Nakae, S. (2018). IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity. Scientific Reports, 8(1), 6639.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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