IL31
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008]
Full Name
Interleukin 31
Function
Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896).
May function in skin immunity (PubMed:15184896).
Enhances myeloid progenitor cell survival in vitro (By similarity).
Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity).
May function in skin immunity (PubMed:15184896).
Enhances myeloid progenitor cell survival in vitro (By similarity).
Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity).
Biological Process
Immune system processIEA:UniProtKB-KW
Cellular Location
Secreted
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Anti-IL31 antibodies
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CompareTarget: IL31
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Rat
Clone: CBYY-I1481
Application*: WB, IC, P, C, E, IP, IF, F
Target: IL31
Sensitivity: 0.0052 ng/mL
Detection Range: 0.01-4 ng/mL
Sample Type: Serum, Plasma, Urine, Ascites, Cerebrospinal fluid, Tissue
Specificity: Dog
Assay Type: Sandwich
Reactivity: Dog
Target: IL31
Sensitivity: 0.0012 ng/mL
Detection Range: 0.002-0.6 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Il31
Sensitivity: 0.0091 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: IL31
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-163
Tag: His Tag
Target: IL31
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 60-190
Tag: His Tag
Target: IL31
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 53-190
Tag: His Tag
Target: IL31
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-163
Tag: His Tag
Target: IL31
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 24-164
Tag: His Tag
Target: IL31
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-164
Tag: His Tag
Target: IL31
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 24-164
Tag: His & AVI Tag
Target: IL31
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 24-164
Tag: His & AVI Tag
Target: IL31
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-163
Tag: His Tag
Target: IL31
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: A552
Application*: ICC, IHC, IP, WB
Target: IL31
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A551
Application*: WB
Target: IL31
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5G9
Application*: WB, E
Target: IL31
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I1577
Application*: E
Target: IL31
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: B-A51
Application*: E, FN
Target: IL31
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-S31
Application*: E, FN
Target: IL31
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-I0205
Application*: IS, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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