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IL31

IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008]
Full Name
Interleukin 31
Function
Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896).
May function in skin immunity (PubMed:15184896).
Enhances myeloid progenitor cell survival in vitro (By similarity).
Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity).
Biological Process
Immune system processIEA:UniProtKB-KW
Cellular Location
Secreted
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Anti-IL31 antibodies

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Mouse Anti-IL31 Recombinant Antibody (CBYY-I1481) (CBMAB-I2651-YY)

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Target: IL31
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Rat
Clone: CBYY-I1481
Application*: WB, IC, P, C, E, IP, IF, F
Datasheet SDS

Mouse Anti-IL31 Recombinant Antibody (A552) (CBMAB-AP3965LY)

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Target: IL31
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: A552
Application*: ICC, IHC, IP, WB
Datasheet SDS

Mouse Anti-IL31 Recombinant Antibody (A551) (CBMAB-AP10885LY)

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Target: IL31
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A551
Application*: WB
Datasheet SDS

Mouse Anti-IL31 Recombinant Antibody (5G9) (CBMAB-A4404-LY)

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Target: IL31
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5G9
Application*: WB, E
Datasheet SDS

Mouse Anti-IL31 Recombinant Antibody (CBYY-I1577) (CBMAB-I2747-YY)

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Target: IL31
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I1577
Application*: E
Datasheet SDS

Mouse Anti-IL31 Recombinant Antibody (B-A51) (CBMAB-I1957-YY)

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Target: IL31
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: B-A51
Application*: E, FN
Datasheet SDS

Mouse Anti-IL31 Recombinant Antibody (B-S31) (CBMAB-I1176-YY)

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Target: IL31
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-S31
Application*: E, FN
Datasheet SDS

Mouse Anti-IL31 Recombinant Antibody (CBYY-I0205) (CBMAB-I0547-YY)

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Target: IL31
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-I0205
Application*: IS, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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