Human Recombinant IL31 protein, His & AVI Tag (V2LY-0526-LY4888)

Name: Human Recombinant IL31 protein, His & AVI Tag
SKU: V2LY-0526-LY4888
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His & AVI Tag

Protein Construction

This product is Human Recombinant IL31 protein, His & AVI Tag consist of Amino Acid: 24-164 and predicts a molecular mass of 19.63 kDa.

Molecule Mass

19.63 kDa

Verified

MALS

Sequence

Amino Acid: 24-164

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥90% as determined by SEC-MALS.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 31

Function

Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896).
May function in skin immunity (PubMed:15184896).
Enhances myeloid progenitor cell survival in vitro (By similarity).
Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity).

Biological Process

Immune system processIEA:UniProtKB-KW

Cellular Location

Secreted

Borgia, F., Custurone, P., Li Pomi, F., Cordiano, R., Alessandrello, C., & Gangemi, S. (2022). IL-31: State of the art for an inflammation-oriented interleukin. International Journal of Molecular Sciences, 23(12), 6507.

Dubin, C., Del Duca, E., & Guttman-Yassky, E. (2021). The IL-4, IL-13 and IL-31 pathways in atopic dermatitis. Expert Review of Clinical Immunology, 17(8), 835-852.

Kunimura, K., & Fukui, Y. (2021). The molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development. International immunology, 33(12), 731-736.

De Martinis, M., Sirufo, M. M., Suppa, M., & Ginaldi, L. (2020). IL-33/IL-31 axis in osteoporosis. International journal of molecular sciences, 21(4), 1239.

Topal, F. A., Zuberbier, T., Makris, M. P., & Hofmann, M. (2020). The role of IL-17, IL-23 and IL-31, IL-33 in allergic skin diseases. Current opinion in allergy and clinical immunology, 20(4), 367-373.

Murdaca, G., Greco, M., Tonacci, A., Negrini, S., Borro, M., Puppo, F., & Gangemi, S. (2019). IL-33/IL-31 axis in immune-mediated and allergic diseases. International journal of molecular sciences, 20(23), 5856.

Miake, S., Tsuji, G., Takemura, M., Hashimoto-Hachiya, A., Vu, Y. H., Furue, M., & Nakahara, T. (2019). IL-4 augments IL-31/IL-31 receptor alpha interaction leading to enhanced Ccl 17 and Ccl 22 production in dendritic cells: implications for atopic dermatitis. International journal of molecular sciences, 20(16), 4053.

Bağci, I. S., & Ruzicka, T. (2018). IL-31: a new key player in dermatology and beyond. Journal of Allergy and Clinical Immunology, 141(3), 858-866.

Di Salvo, E., Ventura-Spagnolo, E., Casciaro, M., Navarra, M., & Gangemi, S. (2018). IL-33/IL-31 axis: a potential inflammatory pathway. Mediators of inflammation, 2018.

Takamori, A., Nambu, A., Sato, K., Yamaguchi, S., Matsuda, K., Numata, T., ... & Nakae, S. (2018). IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity. Scientific Reports, 8(1), 6639.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant IL31 protein, His Tag (CAT#: V2LY-0526-LY1569)

Human Recombinant IL31 protein, His & AVI Tag-1 (CAT#: V2LY-0526-LY4889)

Human Recombinant IL31 protein, His Tag (CAT#: V2LY-0526-LY4890)

Human Recombinant IL31 protein, His Tag-1 (CAT#: V2LY-0526-LY4891)

Mouse Recombinant IL31 protein, His Tag (CAT#: V2LY-0526-LY8534)

Rat Recombinant IL31 protein, His Tag (CAT#: V2LY-0526-LY9475)

Rat Recombinant IL31 protein, His Tag-1 (CAT#: V2LY-0526-LY9476)

Rhesus Recombinant IL31 protein, ECD, His Tag (CAT#: V2LY-0526-LY9754)

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Human Recombinant IL31 protein, His & AVI Tag-1 (CAT#: V2LY-0526-LY4889)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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