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Mouse Anti-IL31 Recombinant Antibody (CBYY-I0205) (CBMAB-I0547-YY)

This product is Mouse antibody that recognizes IL31. The antibody CBYY-I0205 can be used for immunoassay techniques such as: ICFC, WB
See all IL31 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-I0205
Antibody Isotype
IgG2b, κ
Application
ICFC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2, 0.2% (w/v) BSA
Preservative
0.09% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 31
Introduction
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004
Entrez Gene ID
386653
UniProt ID
Q6EBC2
Alternative Names
Interleukin 31
Function
Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896).
May function in skin immunity (PubMed:15184896).
Enhances myeloid progenitor cell survival in vitro (By similarity).
Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity).
Biological Process
Immune system processIEA:UniProtKB-KW
Cellular Location
Secreted

Borgia, F., Custurone, P., Li Pomi, F., Cordiano, R., Alessandrello, C., & Gangemi, S. (2022). IL-31: State of the art for an inflammation-oriented interleukin. International Journal of Molecular Sciences, 23(12), 6507.

Dubin, C., Del Duca, E., & Guttman-Yassky, E. (2021). The IL-4, IL-13 and IL-31 pathways in atopic dermatitis. Expert Review of Clinical Immunology, 17(8), 835-852.

Kunimura, K., & Fukui, Y. (2021). The molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development. International immunology, 33(12), 731-736.

De Martinis, M., Sirufo, M. M., Suppa, M., & Ginaldi, L. (2020). IL-33/IL-31 axis in osteoporosis. International journal of molecular sciences, 21(4), 1239.

Topal, F. A., Zuberbier, T., Makris, M. P., & Hofmann, M. (2020). The role of IL-17, IL-23 and IL-31, IL-33 in allergic skin diseases. Current opinion in allergy and clinical immunology, 20(4), 367-373.

Murdaca, G., Greco, M., Tonacci, A., Negrini, S., Borro, M., Puppo, F., & Gangemi, S. (2019). IL-33/IL-31 axis in immune-mediated and allergic diseases. International journal of molecular sciences, 20(23), 5856.

Miake, S., Tsuji, G., Takemura, M., Hashimoto-Hachiya, A., Vu, Y. H., Furue, M., & Nakahara, T. (2019). IL-4 augments IL-31/IL-31 receptor alpha interaction leading to enhanced Ccl 17 and Ccl 22 production in dendritic cells: implications for atopic dermatitis. International journal of molecular sciences, 20(16), 4053.

Bağci, I. S., & Ruzicka, T. (2018). IL-31: a new key player in dermatology and beyond. Journal of Allergy and Clinical Immunology, 141(3), 858-866.

Di Salvo, E., Ventura-Spagnolo, E., Casciaro, M., Navarra, M., & Gangemi, S. (2018). IL-33/IL-31 axis: a potential inflammatory pathway. Mediators of inflammation, 2018.

Takamori, A., Nambu, A., Sato, K., Yamaguchi, S., Matsuda, K., Numata, T., ... & Nakae, S. (2018). IL-31 is crucial for induction of pruritus, but not inflammation, in contact hypersensitivity. Scientific Reports, 8(1), 6639.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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