Sign in or Register   Sign in or Register
  |  

Recombinant Rat Anti-IL6R Recombinant Antibody (D7715A7) (CBMAB-XB0607-YC)

Provided herein is a Rat Recombinant Antibody against Interleukin 6 Receptor. The antibody can be used for immunoassay techniques, such as FC, IP.
See all IL6R antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
D7715A7
Antibody Isotype
IgG2b
Application
FC, IP

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 6 Receptor
Introduction
IL6R is a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
Entrez Gene ID
16194
UniProt ID
P22272
Alternative Names
Interleukin 6 Receptor

Hamilton, F. W., Thomas, M., Arnold, D., Palmer, T., Moran, E., Mentzer, A. J., ... & Timpson, N. J. (2023). Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A Mendelian randomisation study. PLoS Medicine, 20(1), e1004174.

Maiti, S., Banerjee, A., Nazmeen, A., Kanwar, M., & Das, S. (2022). Active-site molecular docking of nigellidine with nucleocapsid–NSP2–MPro of COVID-19 and to human IL1R–IL6R and strong antioxidant role of Nigella sativa in experimental rats. Journal of Drug Targeting, 30(5), 511-521.

Teoh, P. J., Chung, T. H., Chng, P. Y., Toh, S. H., & Chng, W. J. (2020). IL6R-STAT3-ADAR1 (P150) interplay promotes oncogenicity in multiple myeloma with 1q21 amplification. haematologica, 105(5), 1391.

Strafella, C., Caputo, V., Termine, A., Barati, S., Caltagirone, C., Giardina, E., & Cascella, R. (2020). Investigation of genetic variations of IL6 and IL6R as potential prognostic and pharmacogenetics biomarkers: implications for COVID-19 and neuroinflammatory disorders. Life, 10(12), 351.

Nouri, B., Nair, N., & Barton, A. (2020). Predicting treatment response to IL6R blockers in rheumatoid arthritis. Rheumatology, 59(12), 3603-3610.

Buonaguro, F. M., Puzanov, I., & Ascierto, P. A. (2020). Anti-IL6R role in treatment of COVID-19-related ARDS. Journal of translational medicine, 18, 1-2.

Jia, C., Wang, G., Wang, T., Fu, B., Zhang, Y., Huang, L., ... & Liu, W. (2020). Cancer-associated Fibroblasts induce epithelial-mesenchymal transition via the Transglutaminase 2-dependent IL-6/IL6R/STAT3 axis in Hepatocellular Carcinoma. International journal of biological sciences, 16(14), 2542.

Deng, N., Li, L., Gao, J., Zhou, J., Wang, Y., Wang, C., & Liu, Y. (2018). Hsa_circ_0009910 promotes carcinogenesis by promoting the expression of miR-449a target IL6R in osteosarcoma. Biochemical and biophysical research communications, 495(1), 189-196.

Tamura, Y., Phan, C., Tu, L., Le Hiress, M., Thuillet, R., Jutant, E. M., ... & Guignabert, C. (2018). Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension. The Journal of clinical investigation, 128(5), 1956-1970.

Zhang, B., Yu, L., Han, N., Hu, Z., Wang, S., Ding, L., & Jiang, J. (2018). LINC01116 targets miR-520a-3p and affects IL6R to promote the proliferation and migration of osteosarcoma cells through the Jak-stat signaling pathway. Biomedicine & Pharmacotherapy, 107, 270-282.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Recombinant Rat Anti-IL6R Recombinant Antibody (D7715A7)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare