Mouse Anti-IL7 Recombinant Antibody (CBYY-I0502) (CBMAB-I1158-YY)

Name: Mouse Anti-IL7 Recombinant Antibody (CBYY-I0502)
SKU: CBMAB-I1158-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-I0502

Application

ELISA(Cap)

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Interleukin 7

Introduction

The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.

Entrez Gene ID

3574

UniProt ID

P13232

Alternative Names

Interleukin 7

Function

Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

Biological Process

Animal organ morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Bone resorptionISS:UniProtKB
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Homeostasis of number of cells within a tissueIEA:Ensembl
Humoral immune responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of apoptotic processISS:UniProtKB
Negative regulation of catalytic activityIEA:Ensembl
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIEA:Ensembl
Positive regulation of B cell differentiationIEA:Ensembl
Positive regulation of B cell proliferationISS:UniProtKB
Positive regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of chemokine productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of organ growthIEA:Ensembl
Positive regulation of T cell differentiationISS:UniProtKB
Regulation of peptidyl-tyrosine phosphorylationIEA:Ensembl
T cell lineage commitmentIEA:Ensembl

Cellular Location

Secreted

Involvement in disease

Epidermodysplasia verruciformis 5 (EV5):
A form of epidermodysplasia verruciformis, a rare genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses, including the oncogenic HPV5. Infection leads to the early development of disseminated flat wart-like and pityriasis versicolor-like skin lesions. Cutaneous Bowen's carcinomas in situ and invasive squamous cell carcinomas develop in about half of the patients, mainly on sun-exposed skin areas. EV5 patients shows T-cell lymphopenia, particularly affecting CD4+ T cells. EV5 inheritance is autosomal recessive.

Swan, S. L., Mehta, N., Ilich, E., Shen, S. H., Wilkinson, D. S., Anderson, A. R., ... & Bellamkonda, R. V. (2023). IL7 and IL7 Flt3L co-expressing CAR T cells improve therapeutic efficacy in mouse EGFRvIII heterogeneous glioblastoma. Frontiers in Immunology, 14, 1085547.

Taylor, C. A., Watson, R. A., Tong, O., Ye, W., Nassiri, I., Gilchrist, J. J., ... & Fairfax, B. P. (2022). IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma. Nature Medicine, 28(12), 2592-2600.

Tokunaga, Y., Sasaki, T., Goto, S., Adachi, K., Sakoda, Y., & Tamada, K. (2022). Enhanced antitumor responses of tumor antigen-specific TCR T cells genetically engineered to produce IL7 and CCL19. Molecular cancer therapeutics, 21(1), 138-148.

Omraninava, M., Mehranfar, S., Vahedi, P., Razi, B., Imani, D., Aslani, S., & Feyzinia, S. (2021). Association between IL7 Receptor Alpha (Il7ra) gene rs6897932 polymorphism and the risk of Multiple Sclerosis: A meta-regression and meta-analysis. Multiple sclerosis and related disorders, 48, 102687.

Luo, H., Su, J., Sun, R., Sun, Y., Wang, Y., Dong, Y., ... & Li, Z. (2020). Coexpression of IL7 and CCL21 increases efficacy of CAR-T cells in solid tumors without requiring preconditioned lymphodepletion. Clinical Cancer Research, 26(20), 5494-5505.

Hombach, A. A., Geumann, U., Günther, C., Hermann, F. G., & Abken, H. (2020). IL7-IL12 engineered mesenchymal stem cells (MSCs) improve a CAR T cell attack against colorectal cancer cells. Cells, 9(4), 873.

Park, J. H., Waickman, A. T., Reynolds, J., Castro, M., & Molina‐París, C. (2019). IL7 receptor signaling in T cells: A mathematical modeling perspective. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 11(5), e1447.

Senkevitch, E., Li, W., Hixon, J. A., Andrews, C., Cramer, S. D., Pauly, G. T., ... & Durum, S. K. (2018). Inhibiting Janus Kinase 1 and BCL-2 to treat T cell acute lymphoblastic leukemia with IL7-Rα mutations. Oncotarget, 9(32), 22605.

Patin, E. C., Soulard, D., Fleury, S., Hassane, M., Dombrowicz, D., Faveeuw, C., ... & Paget, C. (2018). Type I IFN receptor signaling controls IL7-dependent accumulation and activity of protumoral IL17A-producing γδT cells in breast cancer. Cancer Research, 78(1), 195-204.

Kilic, U., Elibol, B., Uysal, O., Kilic, E., Yulug, B., Sakul, A. S., & Yildiz, G. B. (2018). Specific alterations in the circulating levels of the SIRT1, TLR4, and IL7 proteins in patients with dementia. Experimental gerontology, 111, 203-209.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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