Human Recombinant IL7, GMP grade, DMF Filed protein (V2LY-0526-LY4953)

Name: Human Recombinant IL7, GMP grade, DMF Filed protein
SKU: V2LY-0526-LY4953
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Protein Construction

This product is Human Recombinant IL7, GMP grade, DMF Filed protein consist of Amino Acid: 26-177 and predicts a molecular mass of 17.5 kDa.

Molecule Mass

17.5 kDa

Verified

HPLC

Sequence

Amino Acid: 26-177

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.

Endotoxin

<10 EU/mg of the protein.

Format

Liquid

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 7

Function

Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

Biological Process

Animal organ morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Bone resorptionISS:UniProtKB
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Homeostasis of number of cells within a tissueIEA:Ensembl
Humoral immune responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of apoptotic processISS:UniProtKB
Negative regulation of catalytic activityIEA:Ensembl
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIEA:Ensembl
Positive regulation of B cell differentiationIEA:Ensembl
Positive regulation of B cell proliferationISS:UniProtKB
Positive regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of chemokine productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of organ growthIEA:Ensembl
Positive regulation of T cell differentiationISS:UniProtKB
Regulation of peptidyl-tyrosine phosphorylationIEA:Ensembl
T cell lineage commitmentIEA:Ensembl

Cellular Location

Secreted

Involvement in disease

Epidermodysplasia verruciformis 5 (EV5):
A form of epidermodysplasia verruciformis, a rare genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses, including the oncogenic HPV5. Infection leads to the early development of disseminated flat wart-like and pityriasis versicolor-like skin lesions. Cutaneous Bowen's carcinomas in situ and invasive squamous cell carcinomas develop in about half of the patients, mainly on sun-exposed skin areas. EV5 patients shows T-cell lymphopenia, particularly affecting CD4+ T cells. EV5 inheritance is autosomal recessive.

Swan, S. L., Mehta, N., Ilich, E., Shen, S. H., Wilkinson, D. S., Anderson, A. R., ... & Bellamkonda, R. V. (2023). IL7 and IL7 Flt3L co-expressing CAR T cells improve therapeutic efficacy in mouse EGFRvIII heterogeneous glioblastoma. Frontiers in Immunology, 14, 1085547.

Taylor, C. A., Watson, R. A., Tong, O., Ye, W., Nassiri, I., Gilchrist, J. J., ... & Fairfax, B. P. (2022). IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma. Nature Medicine, 28(12), 2592-2600.

Tokunaga, Y., Sasaki, T., Goto, S., Adachi, K., Sakoda, Y., & Tamada, K. (2022). Enhanced antitumor responses of tumor antigen-specific TCR T cells genetically engineered to produce IL7 and CCL19. Molecular cancer therapeutics, 21(1), 138-148.

Omraninava, M., Mehranfar, S., Vahedi, P., Razi, B., Imani, D., Aslani, S., & Feyzinia, S. (2021). Association between IL7 Receptor Alpha (Il7ra) gene rs6897932 polymorphism and the risk of Multiple Sclerosis: A meta-regression and meta-analysis. Multiple sclerosis and related disorders, 48, 102687.

Luo, H., Su, J., Sun, R., Sun, Y., Wang, Y., Dong, Y., ... & Li, Z. (2020). Coexpression of IL7 and CCL21 increases efficacy of CAR-T cells in solid tumors without requiring preconditioned lymphodepletion. Clinical Cancer Research, 26(20), 5494-5505.

Hombach, A. A., Geumann, U., Günther, C., Hermann, F. G., & Abken, H. (2020). IL7-IL12 engineered mesenchymal stem cells (MSCs) improve a CAR T cell attack against colorectal cancer cells. Cells, 9(4), 873.

Park, J. H., Waickman, A. T., Reynolds, J., Castro, M., & Molina‐París, C. (2019). IL7 receptor signaling in T cells: A mathematical modeling perspective. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 11(5), e1447.

Senkevitch, E., Li, W., Hixon, J. A., Andrews, C., Cramer, S. D., Pauly, G. T., ... & Durum, S. K. (2018). Inhibiting Janus Kinase 1 and BCL-2 to treat T cell acute lymphoblastic leukemia with IL7-Rα mutations. Oncotarget, 9(32), 22605.

Patin, E. C., Soulard, D., Fleury, S., Hassane, M., Dombrowicz, D., Faveeuw, C., ... & Paget, C. (2018). Type I IFN receptor signaling controls IL7-dependent accumulation and activity of protumoral IL17A-producing γδT cells in breast cancer. Cancer Research, 78(1), 195-204.

Kilic, U., Elibol, B., Uysal, O., Kilic, E., Yulug, B., Sakul, A. S., & Yildiz, G. B. (2018). Specific alterations in the circulating levels of the SIRT1, TLR4, and IL7 proteins in patients with dementia. Experimental gerontology, 111, 203-209.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant IL7 protein, His Tag (CAT#: V2LY-0526-LY1579)

Human Recombinant IL7 protein (CAT#: V2LY-0526-LY4954)

Human Recombinant IL7 protein-1 (CAT#: V2LY-0526-LY4955)

Mouse Recombinant IL7 protein (CAT#: V2LY-0526-LY8553)

Rat Recombinant IL7 protein (CAT#: V2LY-0526-LY9484)

Human Recombinant IL7, GMP grade protein (CAT#: V2LY-0526-LY4952)

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Isotype control

For research use only. Not intended for any clinical use.

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