IL7

The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]

Interleukin 7

Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

Animal organ morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Bone resorptionISS:UniProtKB
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Homeostasis of number of cells within a tissueIEA:Ensembl
Humoral immune responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of apoptotic processISS:UniProtKB
Negative regulation of catalytic activityIEA:Ensembl
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIEA:Ensembl
Positive regulation of B cell differentiationIEA:Ensembl
Positive regulation of B cell proliferationISS:UniProtKB
Positive regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of chemokine productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of organ growthIEA:Ensembl
Positive regulation of T cell differentiationISS:UniProtKB
Regulation of peptidyl-tyrosine phosphorylationIEA:Ensembl
T cell lineage commitmentIEA:Ensembl

Secreted

Epidermodysplasia verruciformis 5 (EV5):
A form of epidermodysplasia verruciformis, a rare genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses, including the oncogenic HPV5. Infection leads to the early development of disseminated flat wart-like and pityriasis versicolor-like skin lesions. Cutaneous Bowen's carcinomas in situ and invasive squamous cell carcinomas develop in about half of the patients, mainly on sun-exposed skin areas. EV5 patients shows T-cell lymphopenia, particularly affecting CD4+ T cells. EV5 inheritance is autosomal recessive.