Mouse Anti-ING1 Recombinant Antibody (1C9) (CBMAB-I0644-YY)

Name: Mouse Anti-ING1 Recombinant Antibody (1C9)
SKU: CBMAB-I0644-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1C9

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG1, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Inhibitor Of Growth Family Member 1

Introduction

This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Entrez Gene ID

3621

UniProt ID

Q9UK53

Alternative Names

Inhibitor Of Growth Family Member 1

Function

Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.

Biological Process

Cell cycleIEA:UniProtKB-KW
Negative regulation of cell growth1 PublicationNAS:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
Protein import into nucleusIEA:Ensembl
Regulation of cell deathIEA:Ensembl
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

Involvement in disease

Squamous cell carcinoma of the head and neck (HNSCC):
A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.

Yang, Y., Ma, B., Djamshidi, M., Zhang, Q., Sarkar, A., Chanda, A., ... & Riabowol, K. (2023). ING1 inhibits Twist1 expression to block EMT and is antagonized by the HDAC inhibitor vorinostat. European Journal of Cell Biology, 102(3), 151341.

Bartsch, S., Mirzakhani, K., Neubert, L., Stenzel, A., Ehsani, M., Esmaeili, M., ... & Baniahmad, A. (2021). Antithetic hTERT regulation by androgens in prostate cancer cells: hTERT inhibition is mediated by the ING1 and ING2 tumor suppressors. Cancers, 13(16), 4025.

Smolle, E., Fink-Neuboeck, N., Lindenmann, J., Smolle-Juettner, F., & Pichler, M. (2019). The biological and clinical relevance of inhibitor of growth (ING) genes in non-Small cell lung cancer. Cancers, 11(8), 1118.

Leighton, L. J., Zhao, Q., Li, X., Dai, C., Marshall, P. R., Liu, S., ... & Wei, W. (2018). A functional role for the epigenetic regulator ING1 in activity-induced gene expression in primary cortical neurons. Neuroscience, 369, 248-260.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

ING1 Matched Antibody Pair (641) (CAT#: APMAB-641LY)

ING1 Matched Antibody Pair (642) (CAT#: APMAB-642LY)

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Rabbit Anti-ING1 Recombinant Antibody (CBYY-I1663) (CAT#: CBMAB-I2833-YY)

ING1 Matched Antibody Pair (641) (CAT#: APMAB-641LY)

Mouse Anti-ING1 Antibody (1C2) (CAT#: CBMAB-0530-YC)

Mouse Anti-ING1 Recombinant Antibody (CBYY-I0246) (CAT#: CBMAB-I0645-YY)

ING1 Matched Antibody Pair (642) (CAT#: APMAB-642LY)

Mouse Anti-ING1 Recombinant Antibody (CBYY-I0631) (CAT#: CBMAB-I1405-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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