ING1

This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Full Name
Inhibitor Of Growth Family Member 1
Function
Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.
Biological Process
Cell cycleIEA:UniProtKB-KW
Negative regulation of cell growth1 PublicationNAS:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
Protein import into nucleusIEA:Ensembl
Regulation of cell deathIEA:Ensembl
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Squamous cell carcinoma of the head and neck (HNSCC):
A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.
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Anti-ING1 antibodies

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Mouse Anti-ING1 Recombinant Antibody (2E1) (CBMAB-A4472-LY)

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Target: ING1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2E1
Application*: WB, E
Datasheet SDS

Recombinant Mouse Anti-ING1 Recombinant Antibody (Cabs 2-9) (CBMAB-XB0617-YC)

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Target: ING1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: Cabs 2-9
Application*: E, IF, WB
Datasheet SDS

Recombinant Mouse Anti-ING1 Recombinant Antibody (Cab 1) (CBMAB-XB0616-YC)

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Target: ING1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: Cab 1
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-ING1 Antibody (1C2) (CBMAB-0530-YC)

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Target: ING1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C2
Application*: WB, M
Datasheet SDS

Human ING1 ELISA Kit (V2LY-0626-LY4717)

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Target: ING1
Sensitivity: 0.0053 ng/mL
Detection Range: 0.01-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Human Recombinant ING1 protein, His Tag (V2LY-0526-LY4995)

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Target: ING1
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: Full Length
Tag: His Tag
Datasheet SDS

ING1 Matched Antibody Pair (642) (APMAB-642LY)

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Target: ING1
Specificity: Human
Datasheet SDS

ING1 Matched Antibody Pair (641) (APMAB-641LY)

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Target: ING1
Specificity: Human
Datasheet SDS

Rabbit Anti-ING1 Recombinant Antibody (CBYY-I1663) (CBMAB-I2833-YY)

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Target: ING1
Host: Rabbit
Specificity: Human, Mouse, Rat, Monkey
Clone: CBYY-I1663
Application*: WB, IP
Datasheet SDS

Mouse Anti-ING1 Recombinant Antibody (CBYY-I1053) (CBMAB-I2221-YY)

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Target: ING1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I1053
Application*: E, WB
Datasheet SDS

Mouse Anti-ING1 Recombinant Antibody (CBYY-I0632) (CBMAB-I1406-YY)

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Target: ING1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0632
Application*: IH
Datasheet SDS

Mouse Anti-ING1 Recombinant Antibody (CBYY-I0631) (CBMAB-I1405-YY)

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Target: ING1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBYY-I0631
Application*: WB
Datasheet SDS

Mouse Anti-ING1 Recombinant Antibody (CBYY-I0246) (CBMAB-I0645-YY)

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Target: ING1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBYY-I0246
Application*: E, WB
Datasheet SDS

Mouse Anti-ING1 Recombinant Antibody (1C9) (CBMAB-I0644-YY)

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Target: ING1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1C9
Application*: E, WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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