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ING1

This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Full Name
Inhibitor Of Growth Family Member 1
Function
Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.
Biological Process
Cell cycleIEA:UniProtKB-KW
Negative regulation of cell growth1 PublicationNAS:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
Protein import into nucleusIEA:Ensembl
Regulation of cell deathIEA:Ensembl
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Squamous cell carcinoma of the head and neck (HNSCC):
A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.

Anti-ING1 antibodies

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Mouse Anti-ING1 Antibody (1C2) (CBMAB-0530-YC)

Datasheet SDS
Target: ING1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C2
Application*: WB, M

Rabbit Anti-ING1 Recombinant Antibody (CBYY-I1663) (CBMAB-I2833-YY)

Datasheet SDS
Target: ING1
Host: Rabbit
Specificity: Human, Mouse, Rat, Monkey
Clone: CBYY-I1663
Application*: WB, IP

Mouse Anti-ING1 Recombinant Antibody (CBYY-I1053) (CBMAB-I2221-YY)

Datasheet SDS
Target: ING1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I1053
Application*: E, WB

Mouse Anti-ING1 Recombinant Antibody (CBYY-I0632) (CBMAB-I1406-YY)

Datasheet SDS
Target: ING1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0632
Application*: IH

Mouse Anti-ING1 Recombinant Antibody (CBYY-I0631) (CBMAB-I1405-YY)

Datasheet SDS
Target: ING1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBYY-I0631
Application*: WB

Mouse Anti-ING1 Recombinant Antibody (CBYY-I0246) (CBMAB-I0645-YY)

Datasheet SDS
Target: ING1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBYY-I0246
Application*: E, WB

Mouse Anti-ING1 Recombinant Antibody (1C9) (CBMAB-I0644-YY)

Datasheet SDS
Target: ING1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1C9
Application*: E, WB

Mouse Anti-ING1 Recombinant Antibody (2E1) (CBMAB-A4472-LY)

Datasheet SDS
Target: ING1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2E1
Application*: WB, E

Recombinant Mouse Anti-ING1 Recombinant Antibody (Cabs 2-9) (CBMAB-XB0617-YC)

Datasheet SDS
Target: ING1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: Cabs 2-9
Application*: E, IF, WB

Recombinant Mouse Anti-ING1 Recombinant Antibody (Cab 1) (CBMAB-XB0616-YC)

Datasheet SDS
Target: ING1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: Cab 1
Application*: E, IF, WB

ING1 Matched Antibody Pair (642) (APMAB-642LY)

Datasheet SDS
Target: ING1
Specificity: Human

ING1 Matched Antibody Pair (641) (APMAB-641LY)

Datasheet SDS
Target: ING1
Specificity: Human
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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