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Recombinant Mouse Anti-ING1 Recombinant Antibody (Cab 1) (CBMAB-XB0616-YC)

Provided herein is a Mouse Recombinant Antibody against Inhibitor Of Growth Family Member 1. The antibody can be used for immunoassay techniques, such as ELISA, IF, WB.
See all ING1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
Cab 1
Antibody Isotype
IgG2a
Application
ELISA, IF, WB

Basic Information

Immunogen
GST-fusion protein
Specificity
Human, Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Inhibitor Of Growth Family Member 1
Introduction
ING1 is a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers.
Entrez Gene ID
Human3621
Mouse26356
UniProt ID
HumanQ9UK53
MouseQ9QXV3
Alternative Names
Inhibitor Of Growth Family Member 1
Function
Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.
Biological Process
Cell cycleIEA:UniProtKB-KW
Negative regulation of cell growth1 PublicationNAS:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
Protein import into nucleusIEA:Ensembl
Regulation of cell deathIEA:Ensembl
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Squamous cell carcinoma of the head and neck (HNSCC):
A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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