Mouse Anti-INHBE Recombinant Antibody (CBYY-I0888) (CBMAB-I2056-YY)

This product is Mouse antibody that recognizes INHBE. The antibody CBYY-I0888 can be used for immunoassay techniques such as: ELISA
See all INHBE antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBYY-I0888

Antibody Isotype

IgG2a, κ

Application

ELISA

Basic Information

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

inhibin, beta E

Introduction

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate an inhibin beta subunit. Inhibins have been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. This gene may be upregulated under conditions of endoplasmic reticulum stress, and this protein may inhibit cellular proliferation and growth in pancreas and liver.

Entrez Gene ID

83729

UniProt ID

P58166

Alternative Names

Inhibin Beta E Subunit

Function

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Biological Process

Positive regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
SMAD protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted

References

Deaton, A. M., Dubey, A., Ward, L. D., Dornbos, P., Flannick, J., AMP-T2D-GENES Consortium, ... & Nioi, P. (2022). Rare loss of function variants in the hepatokine gene INHBE protect from abdominal obesity. Nature Communications, 13(1), 4319.

Akbari, P., Sosina, O. A., Bovijn, J., Landheer, K., Nielsen, J. B., Kim, M., ... & Lotta, L. A. (2022). Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes. Nature Communications, 13(1), 4844.

Xu, Z. B., Gan, M. F., Yu, H. Y., Mo, L. C., Xia, Y. H., Yu, Q. X., & Zheng, J. M. (2022). The Significance of INHBE Expression in the Cancer Cells of Clear-Cell Renal Cell Carcinoma. Urologia Internationalis, 106(4), 376-386.

Sugiyama, M., Kikuchi, A., Misu, H., Igawa, H., Ashihara, M., Kushima, Y., ... & Takamura, T. (2018). Inhibin βE (INHBE) is a possible insulin resistance-associated hepatokine identified by comprehensive gene expression analysis in human liver biopsy samples. PloS one, 13(3), e0194798.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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