Human Recombinant INHBE protein, hFc Tag-1 (V2LY-0526-LY5000)

Name: Human Recombinant INHBE protein, hFc Tag-1
SKU: V2LY-0526-LY5000
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant INHBE protein, hFc Tag consist of Amino Acid: 237-350 and predicts a molecular mass of 40.9 kDa.

Molecule Mass

40.9 kDa

Sequence

Amino Acid: 237-350

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE.

Endotoxin

<0.5 EU/mg protein.

Format

Liquid

Buffer

Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

inhibin, beta E

Function

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Biological Process

Positive regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
SMAD protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted

Deaton, A. M., Dubey, A., Ward, L. D., Dornbos, P., Flannick, J., AMP-T2D-GENES Consortium, ... & Nioi, P. (2022). Rare loss of function variants in the hepatokine gene INHBE protect from abdominal obesity. Nature Communications, 13(1), 4319.

Akbari, P., Sosina, O. A., Bovijn, J., Landheer, K., Nielsen, J. B., Kim, M., ... & Lotta, L. A. (2022). Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes. Nature Communications, 13(1), 4844.

Xu, Z. B., Gan, M. F., Yu, H. Y., Mo, L. C., Xia, Y. H., Yu, Q. X., & Zheng, J. M. (2022). The Significance of INHBE Expression in the Cancer Cells of Clear-Cell Renal Cell Carcinoma. Urologia Internationalis, 106(4), 376-386.

Sugiyama, M., Kikuchi, A., Misu, H., Igawa, H., Ashihara, M., Kushima, Y., ... & Takamura, T. (2018). Inhibin βE (INHBE) is a possible insulin resistance-associated hepatokine identified by comprehensive gene expression analysis in human liver biopsy samples. PloS one, 13(3), e0194798.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant INHBE protein, hFc Tag (CAT#: V2LY-0526-LY4999)

Related Products

Human Recombinant INHBE protein, hFc Tag (CAT#: V2LY-0526-LY4999)

Mouse Anti-INHBE Recombinant Antibody (CBYY-I0888) (CAT#: CBMAB-I2056-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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