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Mouse Anti-IQGAP2 Recombinant Antibody (1B10) (CBMAB-A4508-LY)

The product is antibody recognizes IQGAP2. The antibody 1B10 immunoassay techniques such as: WB, ELISA.
See all IQGAP2 antibodies
Published Data
Fig.1 Effects of IQGAP2 depletion on EXO70.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
1B10
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
IQGAP2 (NP_006624, 343 a.a. ~ 449 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
IQ Motif Containing GTPase Activating Protein 2
Introduction
This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. [provided by RefSeq]
Entrez Gene ID
10788
UniProt ID
Q13576
Function
Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.
Biological Process
Arp2/3 complex-mediated actin nucleationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of actin cytoskeleton reorganizationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of GTPase activityIEA:InterPro
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Thrombin-activated receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Actin cytoskeleton; Cell surface; Cytoplasm; Cytosol; Extracellular exosome; Filopodium; Lamellipodium; Microtubule; Microvillus; Plasma membrane; Secretory granule membrane

Song, F., Dai, Q., Grimm, M. O., & Steinbach, D. (2023). The Antithetic Roles of IQGAP2 and IQGAP3 in Cancers. Cancers, 15(4), 1115.

Song, F., Kotolloshi, R., Gajda, M., Hölzer, M., Grimm, M. O., & Steinbach, D. (2022). Reduced IQGAP2 promotes bladder cancer through regulation of MAPK/ERK pathway and cytokines. International Journal of Molecular Sciences, 23(21), 13508.

Wang, D., Wang, Z., Zhang, L., & Sun, S. (2021). LncRNA PDCD4-AS1 alleviates triple negative breast cancer by increasing expression of IQGAP2 via miR-10b-5p. Translational oncology, 14(1), 100958.

Kumar, D., Patel, S. A., Hassan, M. K., Mohapatra, N., Pattanaik, N., & Dixit, M. (2021). Reduced IQGAP2 expression promotes EMT and inhibits apoptosis by modulating the MEK-ERK and p38 signaling in breast cancer irrespective of ER status. Cell Death & Disease, 12(4), 389.

Tang, T., Wang, J., Zhang, L., Cheng, Y., Saleh, L., Gu, Y., & Zhang, H. (2021). IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL. BMC cancer, 21(1), 603.

Zhang, L., Yang, S. Y., Qi‐Li, F. R., Liu, X. X., Zhang, W. T., Peng, C., ... & Xu, X. (2021). Administration of isoliquiritigenin prevents nonalcoholic fatty liver disease through a novel IQGAP2‐CREB‐SIRT1 axis. Phytotherapy research, 35(7), 3898-3915.

Xu, L., Shao, Y., Ren, L., Liu, X., Li, Y., Xu, J., & Ye, Y. (2020). IQGAP2 inhibits migration and invasion of gastric cancer cells via elevating SHIP2 phosphatase activity. International journal of molecular sciences, 21(6), 1968.

Li, F., Liu, Z., Zhang, B., Jiang, S., Wang, Q., Du, L., ... & Wang, X. (2020). Circular RNA sequencing indicates circ-IQGAP2 and circ-ZC3H6 as noninvasive biomarkers of primary Sjögren’s syndrome. Rheumatology, 59(9), 2603-2615.

Xie, Y., Zheng, L., & Tao, L. (2019). Downregulation of IQGAP2 correlates with prostate cancer recurrence and metastasis. Translational Oncology, 12(2), 236-244.

Ozdemir, E. S., Jang, H., Gursoy, A., Keskin, O., Li, Z., Sacks, D. B., & Nussinov, R. (2018). Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2. Journal of Biological Chemistry, 293(10), 3685-3699.

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For research use only. Not intended for any clinical use.

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