Mouse Anti-IQGAP2 Recombinant Antibody (1B10) (CBMAB-A4508-LY)

Name: Mouse Anti-IQGAP2 Recombinant Antibody (1B10)
SKU: CBMAB-A4508-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1B10

Application

WB, ELISA

Immunogen

IQGAP2 (NP_006624, 343 a.a. ~ 449 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

IQ Motif Containing GTPase Activating Protein 2

Introduction

This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. [provided by RefSeq]

Entrez Gene ID

10788

UniProt ID

Q13576

Function

Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.

Biological Process

Arp2/3 complex-mediated actin nucleationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of actin cytoskeleton reorganizationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of GTPase activityIEA:InterPro
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Thrombin-activated receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Actin cytoskeleton; Cell surface; Cytoplasm; Cytosol; Extracellular exosome; Filopodium; Lamellipodium; Microtubule; Microvillus; Plasma membrane; Secretory granule membrane

Song, F., Dai, Q., Grimm, M. O., & Steinbach, D. (2023). The Antithetic Roles of IQGAP2 and IQGAP3 in Cancers. Cancers, 15(4), 1115.

Song, F., Kotolloshi, R., Gajda, M., Hölzer, M., Grimm, M. O., & Steinbach, D. (2022). Reduced IQGAP2 promotes bladder cancer through regulation of MAPK/ERK pathway and cytokines. International Journal of Molecular Sciences, 23(21), 13508.

Wang, D., Wang, Z., Zhang, L., & Sun, S. (2021). LncRNA PDCD4-AS1 alleviates triple negative breast cancer by increasing expression of IQGAP2 via miR-10b-5p. Translational oncology, 14(1), 100958.

Kumar, D., Patel, S. A., Hassan, M. K., Mohapatra, N., Pattanaik, N., & Dixit, M. (2021). Reduced IQGAP2 expression promotes EMT and inhibits apoptosis by modulating the MEK-ERK and p38 signaling in breast cancer irrespective of ER status. Cell Death & Disease, 12(4), 389.

Tang, T., Wang, J., Zhang, L., Cheng, Y., Saleh, L., Gu, Y., & Zhang, H. (2021). IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL. BMC cancer, 21(1), 603.

Zhang, L., Yang, S. Y., Qi‐Li, F. R., Liu, X. X., Zhang, W. T., Peng, C., ... & Xu, X. (2021). Administration of isoliquiritigenin prevents nonalcoholic fatty liver disease through a novel IQGAP2‐CREB‐SIRT1 axis. Phytotherapy research, 35(7), 3898-3915.

Xu, L., Shao, Y., Ren, L., Liu, X., Li, Y., Xu, J., & Ye, Y. (2020). IQGAP2 inhibits migration and invasion of gastric cancer cells via elevating SHIP2 phosphatase activity. International journal of molecular sciences, 21(6), 1968.

Li, F., Liu, Z., Zhang, B., Jiang, S., Wang, Q., Du, L., ... & Wang, X. (2020). Circular RNA sequencing indicates circ-IQGAP2 and circ-ZC3H6 as noninvasive biomarkers of primary Sjögren’s syndrome. Rheumatology, 59(9), 2603-2615.

Xie, Y., Zheng, L., & Tao, L. (2019). Downregulation of IQGAP2 correlates with prostate cancer recurrence and metastasis. Translational Oncology, 12(2), 236-244.

Ozdemir, E. S., Jang, H., Gursoy, A., Keskin, O., Li, Z., Sacks, D. B., & Nussinov, R. (2018). Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2. Journal of Biological Chemistry, 293(10), 3685-3699.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-IQGAP2 Recombinant Antibody (CBYY-I1478) (CAT#: CBMAB-I2648-YY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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