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Mouse Anti-IQGAP2 Recombinant Antibody (CBYY-I1478) (CBMAB-I2648-YY)

This product is Mouse antibody that recognizes IQGAP2. The antibody CBYY-I1478 can be used for immunoassay techniques such as: WB, IF
See all IQGAP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBYY-I1478
Antibody Isotype
IgG2a
Application
WB, IF

Basic Information

Specificity
Human, Mouse
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
IQ Motif Containing GTPase Activating Protein 2
Introduction
This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. It also acts as a tumor suppressor and has been found to play a role in regulating innate antiviral responses. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human10788
Mouse544963
UniProt ID
HumanQ13576
MouseQ3UQ44
Alternative Names
IQ Motif Containing GTPase Activating Protein 2
Function
Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.
Biological Process
Arp2/3 complex-mediated actin nucleationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of actin cytoskeleton reorganizationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of GTPase activityIEA:InterPro
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Thrombin-activated receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Actin cytoskeleton; Cell surface; Cytoplasm; Cytosol; Extracellular exosome; Filopodium; Lamellipodium; Microtubule; Microvillus; Plasma membrane; Secretory granule membrane

Song, F., Dai, Q., Grimm, M. O., & Steinbach, D. (2023). The Antithetic Roles of IQGAP2 and IQGAP3 in Cancers. Cancers, 15(4), 1115.

Song, F., Kotolloshi, R., Gajda, M., Hölzer, M., Grimm, M. O., & Steinbach, D. (2022). Reduced IQGAP2 promotes bladder cancer through regulation of MAPK/ERK pathway and cytokines. International Journal of Molecular Sciences, 23(21), 13508.

Wang, D., Wang, Z., Zhang, L., & Sun, S. (2021). LncRNA PDCD4-AS1 alleviates triple negative breast cancer by increasing expression of IQGAP2 via miR-10b-5p. Translational oncology, 14(1), 100958.

Kumar, D., Patel, S. A., Hassan, M. K., Mohapatra, N., Pattanaik, N., & Dixit, M. (2021). Reduced IQGAP2 expression promotes EMT and inhibits apoptosis by modulating the MEK-ERK and p38 signaling in breast cancer irrespective of ER status. Cell Death & Disease, 12(4), 389.

Tang, T., Wang, J., Zhang, L., Cheng, Y., Saleh, L., Gu, Y., & Zhang, H. (2021). IQGAP2 acts as an independent prognostic factor and is related to immunosuppression in DLBCL. BMC cancer, 21(1), 603.

Zhang, L., Yang, S. Y., Qi‐Li, F. R., Liu, X. X., Zhang, W. T., Peng, C., ... & Xu, X. (2021). Administration of isoliquiritigenin prevents nonalcoholic fatty liver disease through a novel IQGAP2‐CREB‐SIRT1 axis. Phytotherapy research, 35(7), 3898-3915.

Xu, L., Shao, Y., Ren, L., Liu, X., Li, Y., Xu, J., & Ye, Y. (2020). IQGAP2 inhibits migration and invasion of gastric cancer cells via elevating SHIP2 phosphatase activity. International journal of molecular sciences, 21(6), 1968.

Li, F., Liu, Z., Zhang, B., Jiang, S., Wang, Q., Du, L., ... & Wang, X. (2020). Circular RNA sequencing indicates circ-IQGAP2 and circ-ZC3H6 as noninvasive biomarkers of primary Sjögren’s syndrome. Rheumatology, 59(9), 2603-2615.

Xie, Y., Zheng, L., & Tao, L. (2019). Downregulation of IQGAP2 correlates with prostate cancer recurrence and metastasis. Translational Oncology, 12(2), 236-244.

Ozdemir, E. S., Jang, H., Gursoy, A., Keskin, O., Li, Z., Sacks, D. B., & Nussinov, R. (2018). Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2. Journal of Biological Chemistry, 293(10), 3685-3699.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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