IQGAP2

This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. It also acts as a tumor suppressor and has been found to play a role in regulating innate antiviral responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

Full Name

IQ Motif Containing GTPase Activating Protein 2

Function

Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.

Biological Process

Arp2/3 complex-mediated actin nucleationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of actin cytoskeleton reorganizationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of GTPase activityIEA:InterPro
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Thrombin-activated receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Actin cytoskeleton; Cell surface; Cytoplasm; Cytosol; Extracellular exosome; Filopodium; Lamellipodium; Microtubule; Microvillus; Plasma membrane; Secretory granule membrane