Mouse Anti-ISL2 Recombinant Antibody (1D9) (CBMAB-A4569-LY)

Name: Mouse Anti-ISL2 Recombinant Antibody (1D9)
SKU: CBMAB-A4569-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1D9

Application

WB, ELISA

Immunogen

ISL2 (NP_665804.1, 261 a.a. ~ 358 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

ISL LIM homeobox 2

Entrez Gene ID

64843

UniProt ID

Q96A47

Alternative Names

FLJ10160

Function

Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.

Biological Process

AxonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of neuron differentiationIEA:Ensembl
Neuron developmentManual Assertion Based On ExperimentTAS:BHF-UCL
Neuron fate specificationManual Assertion Based On ExperimentIBA:GO_Central
Peripheral nervous system neuron developmentManual Assertion Based On ExperimentTAS:BHF-UCL
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Retinal ganglion cell axon guidanceIEA:Ensembl
Spinal cord motor neuron cell fate specificationIEA:Ensembl
Visceral motor neuron differentiationIEA:Ensembl

Cellular Location

Nucleus

Mattern, K. M. J., Blancas‐Velázquez, A. S., Ngo, M. T., Bille, S., Hertz, H., Bering, T., & Rath, M. F. (2023). The ISL LIM‐homeobox 2 transcription factor is negatively regulated by circadian adrenergic signaling to repress the expression of Aanat in pinealocytes of the rat pineal gland. Journal of Pineal Research, e12905.

Tufan, T., Yang, J., Tummala, K. S., Cingoz, H., Kuscu, C., Adair, S. J., ... & Adli, M. (2020). ISL2 is an epigenetically silenced tumor suppressor and regulator of metabolism in pancreatic cancer. bioRxiv, 2020-05.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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