Mouse Anti-ITGB5 Recombinant Antibody (CBT4566) (V2LY-0625-LY1864)

Name: Mouse Anti-ITGB5 Recombinant Antibody (CBT4566)
SKU: V2LY-0625-LY1864
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-ITGB5 Recombinant Antibody (CBT4566) (V2LY-0625-LY1864) in ELISA

Mouse Anti-ITGB5 Recombinant Antibody (CBT4566) (V2LY-0625-LY1864) in WB

Mouse Anti-ITGB5 Recombinant Antibody (CBT4566) (V2LY-0625-LY1864) in IF

Mouse Anti-ITGB5 Recombinant Antibody (CBT4566) (V2LY-0625-LY1864) in FC

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT4566

Application

ICC, FC

Immunogen

Purified recombinant fragment of human ITGB5 (AA: 50-319) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
ICC	1:50-1:200
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Integrin Subunit Beta 5

Entrez Gene ID

3693

UniProt ID

P18084

Function

Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.
(Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C.

Biological Process

Cell adhesion mediated by integrinManual Assertion Based On ExperimentIBA:GO_Central
Cell migrationManual Assertion Based On ExperimentIMP:BHF-UCL
Cell-matrix adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Endodermal cell differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Epithelial cell-cell adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Stress fiber assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Membrane

Topology

Extracellular: 24-719
Helical: 720-742
Cytoplasmic: 743-799

Gu, L., Jin, X., Liang, H., Yang, C., & Zhang, Y. (2023). Upregulation of CSNK1A1 induced by ITGB5 confers to hepatocellular carcinoma resistance to sorafenib in vivo by disrupting the EPS15/EGFR complex. Pharmacological Research, 192, 106789.

Liu, D., Liu, S., Fang, Y., Liu, L., & Hu, K. (2022). Comprehensive analysis of the expression and prognosis for ITGBs: identification of ITGB5 as a biomarker of poor prognosis and correlated with immune infiltrates in gastric cancer. Frontiers in Cell and Developmental Biology, 9, 816230.

Wen, X., Chen, S., Chen, X., Qiu, H., Wang, W., Zhang, N., ... & Zhang, L. (2022). ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway. Frontiers in Oncology, 12, 887068.

Yang, Y., Feng, Q., Hu, K., & Cheng, F. (2021). Using CRISPRa and CRISPRi technologies to study the biological functions of ITGB5, TIMP1, and TMEM176B in prostate cancer cells. Frontiers in Molecular Biosciences, 8, 676021.

Wang, W., Liu, Y., Tang, H., Yu, Y., & Zhang, Q. (2019). ITGB5 plays a key role in Escherichia coli F4ac-induced diarrhea in piglets. Frontiers in Immunology, 10, 2834.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

ITGB5 Matched Antibody Pair (652) (CAT#: APMAB-652LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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