Mouse Anti-ITIH4 Recombinant Antibody (A701) (CBMAB-AP3874LY)

Name: Mouse Anti-ITIH4 Recombinant Antibody (A701)
SKU: CBMAB-AP3874LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A701

Application

ICC, IHC, IP, WB

Immunogen

Lys273~Ala424

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Inter-Alpha-Trypsin Inhibitor Heavy Chain Family Member 4

Introduction

The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Entrez Gene ID

3700

UniProt ID

Q14624

Alternative Names

Inter-Alpha-Trypsin Inhibitor Heavy Chain Family Member 4

Function

MAH776Hu21

Biological Process

Acute-phase responseManual Assertion Based On ExperimentIEP:UniProtKB
Hyaluronan metabolic processIEA:InterPro
Response to cytokineManual Assertion Based On ExperimentIEP:UniProtKB

Cellular Location

Secreted

PTM

Cleaved by plasma kallikrein to yield 100 kDa and 35 kDa fragments, and the resulting 100 kDa fragment is further converted to a 70 kDa fragment.
N- and O-glycosylated. In urine, O-linked glycosylation on threonine residues in the region from Thr-719 to Thr-725 consists of core 1 or possibly core 8 glycans. Mainly Hex(HexNAc)(2), but also some Hex(3)(HexNAc)(3). N-glycosylated but not O-glycosylated in plasma.

Laursen, T. L., Bossen, L., Pihl, R., Troldborg, A., Sandahl, T. D., Hansen, A. G., ... & Thiel, S. (2022). Highly increased levels of inter-α-inhibitor heavy chain 4 (ITIH4) in autoimmune cholestatic liver diseases. Journal of Clinical and Translational Hepatology, 10(5), 796.

Pihl, R., Jensen, R. K., Poulsen, E. C., Jensen, L., Hansen, A. G., Thøgersen, I. B., ... & Thiel, S. (2021). ITIH4 acts as a protease inhibitor by a novel inhibitory mechanism. Science advances, 7(2), eaba7381.

Ma, Y., Li, R., Wang, J., Jiang, W., Yuan, X., Cui, J., & Wang, C. (2021). ITIH4, as an inflammation biomarker, mainly increases in bacterial bloodstream infection. Cytokine, 138, 155377.

Sun, Y., Jin, J., Jing, H., Lu, Y., Zhu, Q., Shu, C., ... & Jing, D. (2021). ITIH4 is a novel serum biomarker for early gastric cancer diagnosis. Clinica Chimica Acta, 523, 365-373.

Soler, L., Dąbrowski, R., García, N., Alava, M. A., Lampreave, F., Piñeiro, M., ... & Bochniarz, M. (2019). Acute-phase inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) levels in serum and milk of cows with subclinical mastitis caused by Streptococcus species and coagulase-negative Staphylococcus species. Journal of dairy science, 102(1), 539-546.

Shi, X., Ohta, Y., Liu, X., Shang, J., Morihara, R., Nakano, Y., ... & Abe, K. (2019). Acute anti-inflammatory markers ITIH4 and AHSG in mice brain of a novel Alzheimer’s disease model. Journal of Alzheimer's Disease, 68(4), 1667-1675.

Liang, C., Zhao, T., Li, H., He, F., Zhao, X., Zhang, Y., ... & Guo, J. (2019). Long non-coding RNA ITIH4-AS1 accelerates the proliferation and metastasis of colorectal cancer by activating JAK/STAT3 signaling. Molecular Therapy-Nucleic Acids, 18, 183-193.

Nakamura, N., Hatano, E., Iguchi, K., Sato, M., Kawaguchi, H., Ohtsu, I., ... & Ikegawa, M. (2019). Elevated levels of circulating ITIH4 are associated with hepatocellular carcinoma with nonalcoholic fatty liver disease: from pig model to human study. BMC cancer, 19(1), 1-14.

Li, X., Li, B., Li, B., Guo, T., Sun, Z., Li, X., ... & Zeng, Y. (2018). ITIH4: effective serum marker, early warning and diagnosis, hepatocellular carcinoma. Pathology & Oncology Research, 24, 663-670.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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