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Mouse Anti-ITIH4 Recombinant Antibody (A701) (CBMAB-AP3874LY)

The product is antibody recognizes ITIH4. The antibody A701 immunoassay techniques such as: ICC, IHC, IP, WB.
See all ITIH4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
A701
Antibody Isotype
IgG
Application
ICC, IHC, IP, WB

Basic Information

Immunogen
Lys273~Ala424
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Inter-Alpha-Trypsin Inhibitor Heavy Chain Family Member 4
Introduction
The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Entrez Gene ID
3700
UniProt ID
Q14624
Alternative Names
Inter-Alpha-Trypsin Inhibitor Heavy Chain Family Member 4
Function
Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration.
Biological Process
Acute-phase responseManual Assertion Based On ExperimentIEP:UniProtKB
Hyaluronan metabolic processIEA:InterPro
Response to cytokineManual Assertion Based On ExperimentIEP:UniProtKB
Cellular Location
Secreted
PTM
Cleaved by plasma kallikrein to yield 100 kDa and 35 kDa fragments, and the resulting 100 kDa fragment is further converted to a 70 kDa fragment.
N- and O-glycosylated. In urine, O-linked glycosylation on threonine residues in the region from Thr-719 to Thr-725 consists of core 1 or possibly core 8 glycans. Mainly Hex(HexNAc)(2), but also some Hex(3)(HexNAc)(3). N-glycosylated but not O-glycosylated in plasma.

Laursen, T. L., Bossen, L., Pihl, R., Troldborg, A., Sandahl, T. D., Hansen, A. G., ... & Thiel, S. (2022). Highly increased levels of inter-α-inhibitor heavy chain 4 (ITIH4) in autoimmune cholestatic liver diseases. Journal of Clinical and Translational Hepatology, 10(5), 796.

Pihl, R., Jensen, R. K., Poulsen, E. C., Jensen, L., Hansen, A. G., Thøgersen, I. B., ... & Thiel, S. (2021). ITIH4 acts as a protease inhibitor by a novel inhibitory mechanism. Science advances, 7(2), eaba7381.

Ma, Y., Li, R., Wang, J., Jiang, W., Yuan, X., Cui, J., & Wang, C. (2021). ITIH4, as an inflammation biomarker, mainly increases in bacterial bloodstream infection. Cytokine, 138, 155377.

Sun, Y., Jin, J., Jing, H., Lu, Y., Zhu, Q., Shu, C., ... & Jing, D. (2021). ITIH4 is a novel serum biomarker for early gastric cancer diagnosis. Clinica Chimica Acta, 523, 365-373.

Soler, L., Dąbrowski, R., García, N., Alava, M. A., Lampreave, F., Piñeiro, M., ... & Bochniarz, M. (2019). Acute-phase inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) levels in serum and milk of cows with subclinical mastitis caused by Streptococcus species and coagulase-negative Staphylococcus species. Journal of dairy science, 102(1), 539-546.

Shi, X., Ohta, Y., Liu, X., Shang, J., Morihara, R., Nakano, Y., ... & Abe, K. (2019). Acute anti-inflammatory markers ITIH4 and AHSG in mice brain of a novel Alzheimer’s disease model. Journal of Alzheimer's Disease, 68(4), 1667-1675.

Liang, C., Zhao, T., Li, H., He, F., Zhao, X., Zhang, Y., ... & Guo, J. (2019). Long non-coding RNA ITIH4-AS1 accelerates the proliferation and metastasis of colorectal cancer by activating JAK/STAT3 signaling. Molecular Therapy-Nucleic Acids, 18, 183-193.

Nakamura, N., Hatano, E., Iguchi, K., Sato, M., Kawaguchi, H., Ohtsu, I., ... & Ikegawa, M. (2019). Elevated levels of circulating ITIH4 are associated with hepatocellular carcinoma with nonalcoholic fatty liver disease: from pig model to human study. BMC cancer, 19(1), 1-14.

Li, X., Li, B., Li, B., Guo, T., Sun, Z., Li, X., ... & Zeng, Y. (2018). ITIH4: effective serum marker, early warning and diagnosis, hepatocellular carcinoma. Pathology & Oncology Research, 24, 663-670.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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