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Rat Anti-IZUMO1R Recombinant Antibody (12A5) (CBMAB-F0089-CQ)

This product is a rat antibody that recognizes IZUMO1R. The antibody 12A5 can be used for immunoassay techniques such as: ICFC.
See all IZUMO1R antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
12A5
Antibody Isotype
IgG2b, κ
Application
ICFC

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
IZUMO1 Receptor, JUNO
Introduction
IZUMO1R (IZUMO1 Receptor, JUNO) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Antifolate resistance. Gene Ontology (GO) annotations related to this gene include receptor activity and folic acid binding. An important paralog of this gene is FOLR1.
Entrez Gene ID
64931
UniProt ID
Q9EQF4
Alternative Names
IZUMO1 Receptor, JUNO
Function
Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate.
Biological Process
Cell adhesionISS:UniProtKB
Fusion of sperm to egg plasma membrane involved in single fertilizationISS:UniProtKB
Single fertilizationISS:UniProtKB
Sperm-egg recognitionISS:UniProtKB
Cellular Location
Cell membrane. GPI-anchored at the oolemma.
PTM
The protein is rapidly cleaved following fertilization, being only weakly detectable in zona-intact fertilized eggs at telophase II and undetectable at the pronuclear stage. Sheding is probably required to block to polyspermy and ensuring egg fusion with a single sperm.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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