IZUMO1R

IZUMO1R (IZUMO1 Receptor, JUNO) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Antifolate resistance. Gene Ontology (GO) annotations related to this gene include receptor activity and folic acid binding. An important paralog of this gene is FOLR1.

IZUMO1 Receptor, JUNO

Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate.

Cell adhesionISS:UniProtKB
Fusion of sperm to egg plasma membrane involved in single fertilizationISS:UniProtKB
Single fertilizationISS:UniProtKB
Sperm-egg recognitionISS:UniProtKB

Cell membrane. GPI-anchored at the oolemma.

The protein is rapidly cleaved following fertilization, being only weakly detectable in zona-intact fertilized eggs at telophase II and undetectable at the pronuclear stage. Sheding is probably required to block to polyspermy and ensuring egg fusion with a single sperm.