Rat Anti-IZUMO1R Recombinant Antibody (CBXF-2698) (CBMAB-F3100-CQ)

Name: Rat Anti-IZUMO1R Recombinant Antibody (CBXF-2698)
SKU: CBMAB-F3100-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBXF-2698

Application

Immunogen

E. coli-derived recombinant mouse FOLR4, Gly20-Ser100

Specificity

Mouse

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

Lyophilized from a 0.2 μm filtered solution in PBS with trehalose

Concentration

LYOPH

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

IZUMO1 Receptor, JUNO

Introduction

IZUMO1R (IZUMO1 Receptor, JUNO) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Antifolate resistance. Gene Ontology (GO) annotations related to this gene include receptor activity and folic acid binding. An important paralog of this gene is FOLR1.

Entrez Gene ID

64931

UniProt ID

Q9EQF4

Alternative Names

IZUMO1 Receptor, JUNO

Function

Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate.

Biological Process

Cell adhesionISS:UniProtKB
Fusion of sperm to egg plasma membrane involved in single fertilizationISS:UniProtKB
Single fertilizationISS:UniProtKB
Sperm-egg recognitionISS:UniProtKB

Cellular Location

Cell membrane. GPI-anchored at the oolemma.

PTM

The protein is rapidly cleaved following fertilization, being only weakly detectable in zona-intact fertilized eggs at telophase II and undetectable at the pronuclear stage. Sheding is probably required to block to polyspermy and ensuring egg fusion with a single sperm.

Zarin, P., Shwartz, Y., Ortiz-Lopez, A., Hanna, B. S., Sassone-Corsi, M., Hsu, Y. C., ... & Benoist, C. (2023). Treg cells require Izumo1R to regulate γδT cell-driven inflammation in the skin. Proceedings of the National Academy of Sciences, 120(14), e2221255120.

Wang, H., Hong, X., & Kinsey, W. H. (2021). Sperm–oocyte signaling: the role of IZUMO1R and CD9 in PTK2B activation and actin remodeling at the sperm binding site. Biology of Reproduction, 104(6), 1292-1301.

Nakata, A., Sato, K., Fujishima, Y., Ting, V. G. S., Nakayama, K., Ariyoshi, K., ... & Miura, T. (2021). Evaluation of Global DNA Methylation and Gene Expression of Izumo1 and Izumo1r in Gonads after High-and Low-Dose Radiation in Neonatal Mice. Biology, 10(12), 1270.

Yu, M., Zhao, H., Chen, T., Tian, Y., Li, M., Wu, K., ... & Chen, Z. J. (2018). Mutational analysis of IZUMO1R in women with fertilization failure and polyspermy after in vitro fertilization. Journal of Assisted Reproduction and Genetics, 35, 539-544.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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