Rabbit Anti-JAK1 Recombinant Antibody (A711) (CBMAB-AP10937LY)

Name: Rabbit Anti-JAK1 Recombinant Antibody (A711)
SKU: CBMAB-AP10937LY
Rating: 5 (1 reviews)

See all JAK1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

A711

Application

IHC, WB

Immunogen

Recombinant protein of human JAK1

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Janus kinase 1

Entrez Gene ID

Human	3716
Mouse	16451
Rat	84598

UniProt ID

Human	P23458
Mouse	P52332
Rat	G3V9W2

Alternative Names

JAK 1,JAK1,JAK1A,JAK1B,Janus kinase 1,JTK3,Tyrosine protein kinase JAK1

Function

A11878

Biological Process

Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Interferon-gamma-mediated signaling pathwayTAS:Reactome
Interleukin-2-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Interleukin-6-mediated signaling pathwayTAS:Reactome
Intracellular signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of homotypic cell-cell adhesionManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of sprouting angiogenesisManual Assertion Based On ExperimentIGI:BHF-UCL
Protein localization to cell-cell junctionManual Assertion Based On ExperimentIMP:ARUK-UCL
Protein phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIMP:UniProtKB
Response to antibioticManual Assertion Based On ExperimentIDA:MGI
Type I interferon signaling pathwayTAS:Reactome

Cellular Location

Endomembrane system. Wholly intracellular, possibly membrane associated.

Involvement in disease

Autoinflammation, immune dysregulation, and eosinophilia (AIIDE):
An autosomal dominant disorder characterized by immune dysregulation, severe atopic dermatitis, and chronic gastrointestinal inflammation. Additional features include asthma, food or environmental allergies, as well as poor overall growth with short stature.

PTM

Autophosphorylated (PubMed:7615558).
Phosphorylated on tyrosine residues in response to interferon gamma signaling (PubMed:7615558).
Dephosphorylation of Tyr-1034 and Tyr-1035 by PTPN2 negatively regulates cytokine-mediated signaling (PubMed:11909529).
Ubiquitinated by RNF125; leading to its degradation by the proteasome.

Chapman, S., Kwa, M., Gold, L. S., & Lim, H. W. (2022). Janus kinase inhibitors in dermatology: Part I. A comprehensive review. Journal of the American Academy of Dermatology, 86(2), 406-413.

Roskoski Jr, R. (2022). Janus kinase (JAK) inhibitors in the treatment of neoplastic and inflammatory disorders. Pharmacological Research, 106362.

Spinelli, F. R., Colbert, R. A., & Gadina, M. (2021). JAK1: Number one in the family; number one in inflammation?. Rheumatology, 60(Supplement_2), ii3-ii10.

Fetter, T., Smith, P., Guel, T., Braegelmann, C., Bieber, T., & Wenzel, J. (2020). Selective janus kinase 1 inhibition is a promising therapeutic approach for lupus erythematosus skin lesions. Frontiers in Immunology, 11, 344.

Choy, E. H. (2019). Clinical significance of Janus Kinase inhibitor selectivity. Rheumatology, 58(6), 953-962.

Zak, M., Hanan, E. J., Lupardus, P., Brown, D. G., Robinson, C., Siu, M., ... & Johnson, A. (2019). Discovery of a class of highly potent Janus kinase 1/2 (JAK1/2) inhibitors demonstrating effective cell-based blockade of IL-13 signaling. Bioorganic & medicinal chemistry letters, 29(12), 1522-1531.

Papadopoulou, C., Hong, Y., Omoyinmi, E., Brogan, P. A., & Eleftheriou, D. (2019). Janus kinase 1/2 inhibition with baricitinib in the treatment of juvenile dermatomyositis. Brain, 142(3), e8-e8.

Abdou, A. G., Maraee, A., Yassien, H., & Sarhan, M. (2018). Immunohistochemistry of Janus kinase 1 (JAK1) expression in vitiligo. Journal of Pathology and Translational Medicine, 52(6), 363-368.

Jarocha, D. J., Gadue, P., Tong, W., Newton, R. C., & Poncz, M. (2018). Janus kinase (JAK) 1 inhibition affects both megakaryopoiesis and thrombopoiesis. Blood, 132, 2559.

Wehde, B. L., Rädler, P. D., Shrestha, H., Johnson, S. J., Triplett, A. A., & Wagner, K. U. (2018). Janus kinase 1 plays a critical role in mammary cancer progression. Cell reports, 25(8), 2192-2207.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Rabbit Anti-JAK1 Recombinant Antibody (A711)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-JAK1 Recombinant Antibody (1G1) (CAT#: CBMAB-0099-WJ)

Mouse Anti-JAK1 Recombinant Antibody (A710) (CAT#: CBMAB-AP4042LY)

Mouse Anti-JAK1 Recombinant Antibody (AF28B1) (CAT#: CBMAB-0289-WJ)

Mouse Anti-JAK1 Recombinant Antibody (D1T6W) (CAT#: CBMAB-CP1248-LY)

Mouse Anti-JAK1 Recombinant Antibody (CBWJJ-017) (CAT#: CBMAB-0475-WJ)

Mouse Anti-JAK1 Recombinant Antibody (CBWJJ-018) (CAT#: CBMAB-0476-WJ)

Mouse Anti-JAK1 Recombinant Antibody (EC179) (CAT#: V2LY-0624-LY179)

Mouse Anti-JAK1 Recombinant Antibody (A708) (CAT#: CBMAB-AP10942LY)

Mouse Anti-JAK1 Recombinant Antibody (A709) (CAT#: CBMAB-AP10939LY)

Mouse Anti-JAK1 Recombinant Antibody (9H252) (CAT#: CBMAB-0286-WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry