Mouse Anti-JCHAIN Recombinant Antibody (3H7) (CBMAB-0194-WJ)

Name: Mouse Anti-JCHAIN Recombinant Antibody (3H7)
SKU: CBMAB-0194-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3H7

Application

IHC-P, WB

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

PREDICTED: similar to immunoglobulin J chain

Introduction

JCHAIN (Joining Chain Of Multimeric IgA And IgM) is a Protein Coding gene. Diseases associated with JCHAIN include Alpha Chain Disease and Mu Chain Disease. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall. Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.

Entrez Gene ID

3512

UniProt ID

P01591

Alternative Names

IGJ; JCH; IGCJ

Function

Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers. It also helps to bind these immunoglobulins to secretory component.

Biological Process

Adaptive immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Antibacterial humoral responseManual Assertion Based On ExperimentIDA:UniProtKB
Glomerular filtrationManual Assertion Based On ExperimentIMP:UniProtKB
Humoral immune responseManual Assertion Based On ExperimentIBA:GO_Central
Immune response1 PublicationNAS:UniProtKB
Innate immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of respiratory burstManual Assertion Based On ExperimentIDA:UniProtKB
Protein-containing complex assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Retina homeostasisManual Assertion Based On ExperimentHEP:UniProtKB

Cellular Location

Secreted

Matsumoto, M. L. (2022). Molecular mechanisms of multimeric assembly of IgM and IgA. Annual Review of Immunology, 40, 221-247.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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