JCHAIN
JCHAIN (Joining Chain Of Multimeric IgA And IgM) is a Protein Coding gene. Diseases associated with JCHAIN include Alpha Chain Disease and Mu Chain Disease. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall. Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.
Full Name
PREDICTED: similar to immunoglobulin J chain
Function
Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers. It also helps to bind these immunoglobulins to secretory component.
Biological Process
Adaptive immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Antibacterial humoral responseManual Assertion Based On ExperimentIDA:UniProtKB
Glomerular filtrationManual Assertion Based On ExperimentIMP:UniProtKB
Humoral immune responseManual Assertion Based On ExperimentIBA:GO_Central
Immune response1 PublicationNAS:UniProtKB
Innate immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of respiratory burstManual Assertion Based On ExperimentIDA:UniProtKB
Protein-containing complex assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Retina homeostasisManual Assertion Based On ExperimentHEP:UniProtKB
Antibacterial humoral responseManual Assertion Based On ExperimentIDA:UniProtKB
Glomerular filtrationManual Assertion Based On ExperimentIMP:UniProtKB
Humoral immune responseManual Assertion Based On ExperimentIBA:GO_Central
Immune response1 PublicationNAS:UniProtKB
Innate immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of respiratory burstManual Assertion Based On ExperimentIDA:UniProtKB
Protein-containing complex assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Retina homeostasisManual Assertion Based On ExperimentHEP:UniProtKB
Cellular Location
Secreted
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Anti-JCHAIN antibodies
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CompareTarget: JCHAIN
Sensitivity: 16.25 ng/mL
Detection Range: 30-9000 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: JCHAIN
Expressed Host: E. coli
Sequence: Amino Acid: 23-159
Tag: His Tag
Target: JCHAIN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I2062
Application*: WB, IH
Target: JCHAIN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I2025
Application*: WB, IH, F
Target: JCHAIN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1969
Application*: WB, F
Target: JCHAIN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1957
Application*: WB, IH, F
Target: JCHAIN
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-I1391
Application*: WB, SE
Target: JCHAIN
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: SP105
Application*: IH, P
Target: JCHAIN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Mc19-9
Application*: WB, E, IH, IP, C
Target: JCHAIN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H7
Application*: P, WB
Target: JCHAIN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H2560
Application*: E, IH, IP, WB
Target: JCHAIN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3F8
Application*: P, WB
Target: JCHAIN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2B9
Application*: F, WB
Target: JCHAIN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2B1
Application*: F, P, WB
Target: JCHAIN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLXJ-037
Application*: WB, P
Target: JCHAIN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLXJ-034
Application*: E, C, IP, WB
Target: JCHAIN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLXJ-036
Application*: IH, IP, WB
Target: JCHAIN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLXJ-035
Application*: E, IH, IP, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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