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Mouse Anti-JSRP1 Recombinant Antibody (VF1c) (CBMAB-0456-WJ)

This product is a mouse antibody that recognizes JSRP1. The antibody VF1c can be used for immunoassay techniques such as: IF, WB.
See all JSRP1 antibodies
Published Data
Fig. 1 Immunoblots stained with antibody to the 90 kDa junctional face membrane protein (90 kDa JFP).
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Summary

Host Animal
Mouse
Specificity
Dog, Guinea pig, Mouse, Rabbit, Rat
Clone
VF1c
Antibody Isotype
IgG1
Application
IF, WB

Basic Information

Immunogen
Rabbit skeletal muscle triads
Specificity
Dog, Guinea pig, Mouse, Rabbit, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
junctional sarcoplasmic reticulum protein 1
Introduction
JSRP1 (Junctional Sarcoplasmic Reticulum Protein 1) encodes the protein which is involved in excitation-contraction coupling at the sarcoplasmic reticulum.
Entrez Gene ID
Guinea pig106026119
Mouse71912
Rat690423
Dog612184
UniProt ID
Guinea pigH0UX49
MouseQ3MI48
RatD4A2V6
Alternative Names
JP45; JP-45
Function
Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity.
Biological Process
Regulation of ryanodine-sensitive calcium-release channel activityManual Assertion Based On ExperimentIBA:GO_Central
Skeletal muscle contractionManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Sarcoplasmic reticulum membrane; Endoplasmic reticulum membrane. Colocalizes with ryanodine receptors at the sarcoplasmic reticulum triad membranes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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