JSRP1

The sarcoplasmic reticulum (SR) is an intracellular membrane compartment that controls intracellular calcium concentration and therefore plays a role in excitation-contraction coupling. In mouse skeletal muscle, Jp45 interacts with key proteins involved in excitation-contraction coupling at the SR (Anderson et al., 2003 [PubMed 12871958]).[supplied by OMIM

Full Name

junctional sarcoplasmic reticulum protein 1

Function

Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S. EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity.

Biological Process

Regulation of ryanodine-sensitive calcium-release channel activityManual Assertion Based On ExperimentIBA:GO_Central
Skeletal muscle contractionManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Sarcoplasmic reticulum membrane; Endoplasmic reticulum membrane. Colocalizes with ryanodine receptors at the sarcoplasmic reticulum triad membranes.