Mouse Anti-AIMP2 Recombinant Antibody (V2-614851) (CBMAB-A4625-LY)

Name: Mouse Anti-AIMP2 Recombinant Antibody (V2-614851)
SKU: CBMAB-A4625-LY
Rating: 5 (1 reviews)

See all AIMP2 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-614851

Application

WB, ELISA

Immunogen

MPMYQVKPYHGGGAPLRVELPTCMYRLPNVHGRSYGPAPG AGHVQEESNLSLQALESRQDDILKRLYELKAAVDGLSKMI QTPDADLDVTNIIQADEPTT

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2

Introduction

The JTV1 gene is located on chromosome 7p22 flanked by two genes, HRI and PMS2. JTV1 and HRI overlap slightly and are arranged in a tail-to-tail fashion. JTV1 and PMS2 are separated by approximately 200 base pairs and are arranged head-to-head. JTV1 is transcribed in the opposite direction compared to HRI and PMS2. The function of the JTV1 gene product is unknown. [provided by RefSeq]

Entrez Gene ID

7965

UniProt ID

Q13155

Alternative Names

AIMP2; P38; PRO0992

Function

Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:19131329). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.

Biological Process

Apoptotic process Source: UniProtKB-KW
Negative regulation of cell population proliferation Source: Ensembl
Positive regulation of aminoacyl-tRNA ligase activity Source: GO_Central
Positive regulation of neuron death Source: Ensembl
Positive regulation of protein ubiquitination Source: Ensembl
Protein-containing complex assembly Source: Ensembl
tRNA aminoacylation for protein translation Source: Reactome
Type II pneumocyte differentiation Source: Ensembl

Cellular Location

Cytosol; Nucleus. Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus.

Involvement in disease

Leukodystrophy, hypomyelinating, 17 (HLD17): An autosomal recessive neurodevelopmental disorder characterized by atrophy of cerebral cortex, spinal cord and cerebellum, thin corpus callosum, abnormal signals in the basal ganglia, and features suggesting hypo- or demyelination observed on brain imaging. Clinical manifestations include lack of development, absent speech, microcephaly, spasticity, seizures, and contractures.

PTM

Phosphorylated on serine residues in response to UV irradiation.
Ubiquitinated by PRKN, leading to its degradation by the proteasome. Mutant PRKN fails to ubiquitinate AIMP2 efficiently, allowing its accumulation which may contribute to neurodegeneration associated with Parkinson disease.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-AIMP2 Recombinant Antibody (V2-614851)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-AIMP2 Recombinant Antibody (V2-180360) (CAT#: CBMAB-A1822-YC)

Mouse Anti-AIMP2 Recombinant Antibody (V2-11278) (CAT#: CBMAB-0027-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry