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Mouse Anti-KBTBD8 Recombinant Antibody (7G8A6) (CBMAB-K0046-LY)

This product is antibody recognizes KBTBD8. The antibody 7G8A6 immunoassay techniques such as: WB, FC, IHC, ICC.
See all KBTBD8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
7G8A6
Antibody Isotype
IgG
Application
WB, FC, IHC, ICC

Basic Information

Immunogen
Purified recombinant fragment of human KBTBD8 (AA: 264-464) expressed in E. Coli
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
KBTBD8
Introduction
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).
Entrez Gene ID
84541
UniProt ID
Q8NFY9
Alternative Names
Kelch Repeat And BTB Domain Containing 8; T-Cell Activation Kelch Repeat Protein; Kelch Repeat And BTB (POZ) Domain Containing 8; TA-KRP; TAKRP; Kelch Repeat And BTB Domain-Containing Protein 8; KIAA1842;
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832).
The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).
Biological Process
Neural crest cell developmentManual Assertion Based On ExperimentIMP:UniProtKB
Neural crest formationManual Assertion Based On ExperimentIMP:UniProtKB
Protein monoubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of translationIEA:UniProtKB-KW
Cellular Location
Cytoplasm, cytoskeleton, spindle; Golgi apparatus. Translocates to the spindle apparatus during mitosis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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