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KBTBD8

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).

Full Name

KBTBD8

Function

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832).
The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).

Biological Process

Neural crest cell developmentManual Assertion Based On ExperimentIMP:UniProtKB
Neural crest formationManual Assertion Based On ExperimentIMP:UniProtKB
Protein monoubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of translationIEA:UniProtKB-KW

Cellular Location

Cytoplasm, cytoskeleton, spindle; Golgi apparatus. Translocates to the spindle apparatus during mitosis.

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Anti-KBTBD8 antibodies

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Mouse Anti-KBTBD8 Recombinant Antibody (5B5-F11-A8) (CBMAB-Z0289-LY)

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Target: KBTBD8

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5B5-F11-A8

Application*: WB, IH, IC, F

Mouse Anti-KBTBD8 Recombinant Antibody (CBT3430) (V2LY-0625-LY238)

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Target: KBTBD8

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT3430

Application*: WB, F

Rabbit Anti-KBTBD8 Recombinant Antibody (CBLY1-043) (CBMAB-K0462-LY)

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Target: KBTBD8

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBLY1-043

Application*: WB, F

Mouse Anti-KBTBD8 Recombinant Antibody (7G8A6) (CBMAB-K0046-LY)

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Target: KBTBD8

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 7G8A6

Application*: WB, F, IH, IC

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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