KBTBD8

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).
Full Name
KBTBD8
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832).
The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).
Biological Process
Neural crest cell developmentManual Assertion Based On ExperimentIMP:UniProtKB
Neural crest formationManual Assertion Based On ExperimentIMP:UniProtKB
Protein monoubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of translationIEA:UniProtKB-KW
Cellular Location
Cytoplasm, cytoskeleton, spindle; Golgi apparatus. Translocates to the spindle apparatus during mitosis.
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Anti-KBTBD8 antibodies

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Mouse Anti-KBTBD8 Recombinant Antibody (5B5-F11-A8) (CBMAB-Z0289-LY)

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Target: KBTBD8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5B5-F11-A8
Application*: WB, IH, IC, F
Datasheet SDS

Mouse Anti-KBTBD8 Recombinant Antibody (CBT3430) (V2LY-0625-LY238)

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Target: KBTBD8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3430
Application*: WB, F
Datasheet SDS

Rabbit Anti-KBTBD8 Recombinant Antibody (CBLY1-043) (CBMAB-K0462-LY)

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Target: KBTBD8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBLY1-043
Application*: WB, F
Datasheet SDS

Mouse Anti-KBTBD8 Recombinant Antibody (7G8A6) (CBMAB-K0046-LY)

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Target: KBTBD8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 7G8A6
Application*: WB, F, IH, IC
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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