Mouse Anti-KCNK10 Recombinant Antibody (1C1) (CBMAB-K0587-LY)

Name: Mouse Anti-KCNK10 Recombinant Antibody (1C1)
SKU: CBMAB-K0587-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1C1

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to aa439-539 from human KCNK10 with GST tag. MW of the GST tag alone is 26kD

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

potassium channel, subfamily K, member 10

Introduction

The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]

Entrez Gene ID

54207

UniProt ID

P57789

Alternative Names

Potassium Two Pore Domain Channel Subfamily K Member 10; Potassium Channel; Two Pore Domain Subfamily K; Member 10; Outward Rectifying Potassium Channel Protein TREK-2; Protein Phosphatase 1; Regulatory Subunit 97; Potassium Channel; Subfamily K; Member 10; TREK-2 K(+) Channel Subunit; TREK2; Potassium Channel Subfamily K Member 10;

Function

Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.

Biological Process

MemoryIEA:Ensembl
Potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Regulation of ion transmembrane transportIEA:UniProtKB-KW
Signal transduction1 PublicationNAS:ProtInc
Stabilization of membrane potentialManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane

Topology

Cytoplasmic: 1-71
Helical: 72-92
Pore-forming: 154-180
Helical: 182-202
Cytoplasmic: 203-233
Helical: 234-254
Pore-forming: 263-294
Helical: 299-319
Cytoplasmic: 320-538

Choi, S. W., Woo, J., Park, K. S., Ko, J., Jeon, Y. K., Choi, S. W., ... & Kim, S. J. (2021). Higher expression of KCNK10 (TREK-2) K+ channels and their functional upregulation by lipopolysaccharide treatment in mouse peritoneal B1a cells. Pflügers Archiv-European Journal of Physiology, 473, 659-671.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-KCNK10 Recombinant Antibody (CBYJT-1410) (CAT#: CBMAB-T0432-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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