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Rabbit Anti-KDM4B Recombinant Antibody (D7E6) (CBMAB-CP1269-LY)

The product is antibody recognizes KDM4B. The antibody D7E6 immunoassay techniques such as: WB,IP,IF (ICC).
See all KDM4B antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
D7E6
Antibody Isotype
IgG
Application
WB, IP, IF (ICC)

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human JMJD2B protein.
Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
lysine demethylase 4B
Introduction
Histone demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 Lys-4, H3 Lys-27, H3 Lys-36 nor H4 Lys-20. Only able to demethylate trimethylated H3 Lys-9, with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.
Entrez Gene ID
Human23030
Monkey695760
UniProt ID
HumanO94953
MonkeyF7E2F6
Alternative Names
Lysine Demethylase 4B; JmjC Domain-Containing Histone Demethylation Protein 3B; Jumonji Domain-Containing Protein 2B; Lysine (K)-Specific Demethylase 4B; Jumonji Domain Containing 2B; Tudor Domain Containing 14B; JMJD2B;
Function
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.
Biological Process
Chromatin remodelingManual Assertion Based On ExperimentIBA:GO_Central
Histone H3-K36 demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H3-K9 demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus

Wang, Z., Cai, H., Zhao, E., & Cui, H. (2022). The diverse roles of histone demethylase KDM4B in normal and cancer development and progression. Frontiers in Cell and Developmental Biology, 9, 790129.

Deng, P., Yuan, Q., Cheng, Y., Li, J., Liu, Z., Liu, Y., ... & Wang, C. Y. (2021). Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging. Cell stem cell, 28(6), 1057-1073.

Wu, M. J., Chen, C. J., Lin, T. Y., Liu, Y. Y., Tseng, L. L., Cheng, M. L., ... & Wang, W. C. (2021). Targeting KDM4B that coactivates c-Myc-regulated metabolism to suppress tumor growth in castration-resistant prostate cancer. Theranostics, 11(16), 7779.

Mak, K. H. M., Lam, Y. M., & Ng, R. K. (2021). Histone demethylase JMJD2B/KDM4B regulates transcriptional program via distinctive epigenetic targets and protein interactors for the maintenance of trophoblast stem cells. Scientific reports, 11(1), 884.

Sha, J., Han, Q., Chi, C., Zhu, Y., Pan, J., Dong, B., ... & Xue, W. (2020). Upregulated KDM4B promotes prostate cancer cell proliferation by activating autophagy. Journal of cellular physiology, 235(3), 2129-2138.

Jing, J. C., Feng, Z., Chen, Z. H., Ji, B. N., Hong, J., Tang, N., ... & Wang, S. Y. (2019). KDM4B promotes gastric cancer metastasis by regulating miR‐125b‐mediated activation of Wnt signaling. Journal of cellular biochemistry, 120(5), 7897-7906.

Wilson, C., & Krieg, A. J. (2019). KDM4B: a nail for every hammer?. Genes, 10(2), 134.

Duan, L., Chen, Z., Lu, J., Liang, Y., Wang, M., Roggero, C. M., ... & Liu, Z. P. (2019). Histone lysine demethylase KDM4B regulates the alternative splicing of the androgen receptor in response to androgen deprivation. Nucleic acids research, 47(22), 11623-11636.

Xiang, Y., Yan, K., Zheng, Q., Ke, H., Cheng, J., Xiong, W., ... & Li, F. (2019). Histone demethylase KDM4B promotes DNA damage by activating long interspersed nuclear element-1. Cancer Research, 79(1), 86-98.

Cheng, Y., Yuan, Q., Vergnes, L., Rong, X., Youn, J. Y., Li, J., ... & Wang, C. Y. (2018). KDM4B protects against obesity and metabolic dysfunction. Proceedings of the National Academy of Sciences, 115(24), E5566-E5575.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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