Mouse Recombinant KDM4B protein, GST Tag (V2LY-0526-LY8587)

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Basic Information

Expressed Host
Baculovirus-Insect Cells
Protein Species
Mouse
Tag
GST Tag
Protein Construction
This product is Mouse Recombinant KDM4B protein, GST Tag consist of Amino Acid: 1-725 and predicts a molecular mass of 125 kDa.
Molecule Mass
125 kDa
Sequence
Amino Acid: 1-725
Species
Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
Batch dependent.
Endotoxin
Please contact us for more information.
Format
Liquid
Buffer
Tris, NaCl, Urea
Preservative
None
Storage
Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
More Infomation

Target

Full Name
lysine demethylase 4B
Function
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.
Biological Process
Chromatin remodelingManual Assertion Based On ExperimentIBA:GO_Central
Histone H3-K36 demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H3-K9 demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus

Wang, Z., Cai, H., Zhao, E., & Cui, H. (2022). The diverse roles of histone demethylase KDM4B in normal and cancer development and progression. Frontiers in Cell and Developmental Biology, 9, 790129.

Deng, P., Yuan, Q., Cheng, Y., Li, J., Liu, Z., Liu, Y., ... & Wang, C. Y. (2021). Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging. Cell stem cell, 28(6), 1057-1073.

Wu, M. J., Chen, C. J., Lin, T. Y., Liu, Y. Y., Tseng, L. L., Cheng, M. L., ... & Wang, W. C. (2021). Targeting KDM4B that coactivates c-Myc-regulated metabolism to suppress tumor growth in castration-resistant prostate cancer. Theranostics, 11(16), 7779.

Mak, K. H. M., Lam, Y. M., & Ng, R. K. (2021). Histone demethylase JMJD2B/KDM4B regulates transcriptional program via distinctive epigenetic targets and protein interactors for the maintenance of trophoblast stem cells. Scientific reports, 11(1), 884.

Sha, J., Han, Q., Chi, C., Zhu, Y., Pan, J., Dong, B., ... & Xue, W. (2020). Upregulated KDM4B promotes prostate cancer cell proliferation by activating autophagy. Journal of cellular physiology, 235(3), 2129-2138.

Jing, J. C., Feng, Z., Chen, Z. H., Ji, B. N., Hong, J., Tang, N., ... & Wang, S. Y. (2019). KDM4B promotes gastric cancer metastasis by regulating miR‐125b‐mediated activation of Wnt signaling. Journal of cellular biochemistry, 120(5), 7897-7906.

Wilson, C., & Krieg, A. J. (2019). KDM4B: a nail for every hammer?. Genes, 10(2), 134.

Duan, L., Chen, Z., Lu, J., Liang, Y., Wang, M., Roggero, C. M., ... & Liu, Z. P. (2019). Histone lysine demethylase KDM4B regulates the alternative splicing of the androgen receptor in response to androgen deprivation. Nucleic acids research, 47(22), 11623-11636.

Xiang, Y., Yan, K., Zheng, Q., Ke, H., Cheng, J., Xiong, W., ... & Li, F. (2019). Histone demethylase KDM4B promotes DNA damage by activating long interspersed nuclear element-1. Cancer Research, 79(1), 86-98.

Cheng, Y., Yuan, Q., Vergnes, L., Rong, X., Youn, J. Y., Li, J., ... & Wang, C. Y. (2018). KDM4B protects against obesity and metabolic dysfunction. Proceedings of the National Academy of Sciences, 115(24), E5566-E5575.

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For research use only. Not intended for any clinical use.

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