Mouse Anti-KDM6A Recombinant Antibody (EG1783) (CBMAB-EN2126-LY)

Name: Mouse Anti-KDM6A Recombinant Antibody (EG1783)
SKU: CBMAB-EN2126-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

EG1783

Application

ELISA, WB

Immunogen

Recombinant fragment of Human KDM6A (N-terminus).

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Lysine Demethylase 6A

Introduction

This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]

Entrez Gene ID

7403

UniProt ID

O15550

Alternative Names

Lysine Demethylase 6A; Lysine (K)-Specific Demethylase 6A; Histone Demethylase UTX; UTX; BA386N14.2 (Ubiquitously Transcribed X Chromosome Tetratricopeptide Repeat Protein (UTX)); Ubiquitously-Transcribed X Chromosome Tetratricopeptide Repeat Protein; Ubiquitously Transcribed Tetratricopeptide Repeat Protein X-Linked; Ubiquitously Transcribed Tetratricopeptide Repeat, X Chromosome;

Function

Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17851529, PubMed:17713478, PubMed:17761849).
Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17851529, PubMed:17713478, PubMed:17761849).
Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529).
Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849).
Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity).

Biological Process

Chromatin remodelingISS:UniProtKB
Heart developmentManual Assertion Based On ExperimentIBA:GO_Central
Histone H3-K27 demethylationManual Assertion Based On ExperimentIBA:GO_Central
Histone H3-K4 methylationBy SimilarityISS:UniProtKB
Regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus

Involvement in disease

Kabuki syndrome 2 (KABUK2):
A congenital mental retardation syndrome with additional features, including postnatal dwarfism, a peculiar facies characterized by long palpebral fissures with eversion of the lateral third of the lower eyelids, a broad and depressed nasal tip, large prominent earlobes, a cleft or high-arched palate, scoliosis, short fifth finger, persistence of fingerpads, radiographic abnormalities of the vertebrae, hands, and hip joints, and recurrent otitis media in infancy.

Duplaquet, L., Li, Y., Booker, M. A., Xie, Y., Olsen, S. N., Patel, R. A., ... & Oser, M. G. (2023). KDM6A epigenetically regulates subtype plasticity in small cell lung cancer. Nature Cell Biology, 25(9), 1346-1358.

Tran, N., Broun, A., & Ge, K. (2020). Lysine demethylase KDM6A in differentiation, development, and cancer. Molecular and cellular biology.

Stief, S. M., Hanneforth, A. L., Weser, S., Mattes, R., Carlet, M., Liu, W. H., ... & Spiekermann, K. (2020). Loss of KDM6A confers drug resistance in acute myeloid leukemia. Leukemia, 34(1), 50-62.

Gažová, I., Lengeling, A., & Summers, K. M. (2019). Lysine demethylases KDM6A and UTY: The X and Y of histone demethylation. Molecular genetics and metabolism, 127(1), 31-44.

Schulz, W. A., Lang, A., Koch, J., & Greife, A. (2019). The histone demethylase UTX/KDM6A in cancer: Progress and puzzles. International journal of cancer, 145(3), 614-620.

Chakraborty, A. A., Laukka, T., Myllykoski, M., Ringel, A. E., Booker, M. A., Tolstorukov, M. Y., ... & Kaelin Jr, W. G. (2019). Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate. Science, 363(6432), 1217-1222.

Itoh, Y., Golden, L. C., Itoh, N., Matsukawa, M. A., Ren, E., Tse, V., ... & Voskuhl, R. R. (2019). The X-linked histone demethylase Kdm6a in CD4+ T lymphocytes modulates autoimmunity. The Journal of clinical investigation, 129(9), 3852-3863.

Zhou, C., Wang, Y., Zhang, J., Su, J., An, Q., Liu, X., ... & Zhang, Y. (2019). H3K27me3 is an epigenetic barrier while KDM6A overexpression improves nuclear reprogramming efficiency. The FASEB Journal, 33(3), 4638-4652.

Cui, Y., Yan, H., Wang, K., Xu, H., Zhang, X., Zhu, H., ... & Pan, C. (2018). Insertion/deletion within the KDM6A gene is significantly associated with litter size in goat. Frontiers in Genetics, 9, 91.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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For research use only. Not intended for any clinical use.

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