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KDM6A

This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]
Full Name
Lysine Demethylase 6A
Function
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17851529, PubMed:17713478, PubMed:17761849).
Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27' (PubMed:17851529, PubMed:17713478, PubMed:17761849).
Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529).
Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (PubMed:17761849).
Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression (By similarity).
Biological Process
Chromatin remodelingISS:UniProtKB
Heart developmentManual Assertion Based On ExperimentIBA:GO_Central
Histone H3-K27 demethylationManual Assertion Based On ExperimentIBA:GO_Central
Histone H3-K4 methylationBy SimilarityISS:UniProtKB
Regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Involvement in disease
Kabuki syndrome 2 (KABUK2):
A congenital mental retardation syndrome with additional features, including postnatal dwarfism, a peculiar facies characterized by long palpebral fissures with eversion of the lateral third of the lower eyelids, a broad and depressed nasal tip, large prominent earlobes, a cleft or high-arched palate, scoliosis, short fifth finger, persistence of fingerpads, radiographic abnormalities of the vertebrae, hands, and hip joints, and recurrent otitis media in infancy.
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Anti-KDM6A antibodies

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Mouse Anti-KDM6A Recombinant Antibody (3A2) (CBMAB-K0711-LY)

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Target: KDM6A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human
Clone: 3A2
Application*: WB, IP, E, F
Datasheet SDS

Mouse Anti-KDM6A Recombinant Antibody (CBXU-016) (CBMAB-U0132-CQ)

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Target: KDM6A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXU-016
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-KDM6A Recombinant Antibody (6E2D6) (CBMAB-K0714-LY)

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Target: KDM6A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat
Clone: 6E2D6
Application*: E, WB
Datasheet SDS

Mouse Anti-KDM6A Recombinant Antibody (5C2A9) (CBMAB-K0713-LY)

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Target: KDM6A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5C2A9
Application*: E, WB, F
Datasheet SDS

Mouse Anti-KDM6A Recombinant Antibody (1612) (CBMAB-K0710-LY)

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Target: KDM6A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1612
Application*: WB
Datasheet SDS

Mouse Anti-KDM6A Recombinant Antibody (CBT3356) (V2LY-0625-LY450)

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Target: KDM6A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT3356
Application*: F
Datasheet SDS

Mouse Anti-KDM6A Recombinant Antibody (CBT4129) (V2LY-0625-LY449)

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Target: KDM6A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat
Clone: CBT4129
Application*: WB
Datasheet SDS

Mouse Anti-KDM6A Recombinant Antibody (EG1783) (CBMAB-EN2126-LY)

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Target: KDM6A
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: EG1783
Application*: ELISA, WB
Datasheet SDS

Rabbit Anti-KDM6A Recombinant Antibody (D3Q1I) (CBMAB-CP2958-LY)

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Target: KDM6A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D3Q1I
Application*: WB, IP, P
Datasheet SDS

Rabbit Anti-KDM6A Recombinant Antibody (CBXU-146) (CBMAB-U0219-CQ)

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Target: KDM6A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBXU-146
Application*: WB, IP, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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