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Mouse Anti-KIF25 Recombinant Antibody (2C9) (CBMAB-K0867-LY)

This product is antibody recognizes KIF25. The antibody 2C9 immunoassay techniques such as: IF, IHC, WB.
See all KIF25 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2C9
Antibody Isotype
IgG1
Application
IF, IHC, WB

Basic Information

Immunogen
Full length human recombinant protein of human KIF25(NP_005346) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Kinesin Family Member 25
Introduction
The protein encoded by this gene is a member of the kinesin-like protein family. Protein family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. However, the particular function of this gene product has not yet been determined. Two alternatively spliced transcript variants which encode products have been described. Other splice variants have been found that lack exon 2 and the initiation codon for translation. [provided by RefSeq, Jul 2008]
Entrez Gene ID
UniProt ID
Alternative Names
Kinesin Family Member 25; Kinesin-Like Protein 3; Kinesin-Like 3; KNSL3; Kinesin-Like Protein KIF25;
Function
Minus-end microtubule-dependent motor protein (By similarity).
Acts as a negative regulator of centrosome separation required to prevent premature centrosome separation during interphase (PubMed:28263957).
Required to maintain a centered nucleus to ensure that the spindle is stably oriented at the onset of mitosis (PubMed:28263957).
May also act as a negative regulator of amino acid starvation-induced autophagy (PubMed:22354037).
Biological Process
Establishment of spindle orientationManual Assertion Based On ExperimentIDA:UniProtKB
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Mitotic sister chromatid segregationManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of autophagyManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of mitotic centrosome separationManual Assertion Based On ExperimentIDA:UniProtKB
Nucleus localizationManual Assertion Based On ExperimentIDA:UniProtKB
Organelle organizationManual Assertion Based On ExperimentTAS:ProtInc
Protein homotetramerizationISS:UniProtKB
Cellular Location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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