KIF25

The protein encoded by this gene is a member of the kinesin-like protein family. Protein family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. However, the particular function of this gene product has not yet been determined. Two alternatively spliced transcript variants which encode products have been described. Other splice variants have been found that lack exon 2 and the initiation codon for translation. [provided by RefSeq, Jul 2008]

Full Name

Kinesin Family Member 25

Function

Minus-end microtubule-dependent motor protein (By similarity).
Acts as a negative regulator of centrosome separation required to prevent premature centrosome separation during interphase (PubMed:28263957).
Required to maintain a centered nucleus to ensure that the spindle is stably oriented at the onset of mitosis (PubMed:28263957).
May also act as a negative regulator of amino acid starvation-induced autophagy (PubMed:22354037).

Biological Process

Establishment of spindle orientationManual Assertion Based On ExperimentIDA:UniProtKB
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Mitotic sister chromatid segregationManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of autophagyManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of mitotic centrosome separationManual Assertion Based On ExperimentIDA:UniProtKB
Nucleus localizationManual Assertion Based On ExperimentIDA:UniProtKB
Organelle organizationManual Assertion Based On ExperimentTAS:ProtInc
Protein homotetramerizationISS:UniProtKB

Cellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome