Mouse Anti-KIF3B Recombinant Antibody (8H4) (CBMAB-K0885-LY)

Name: Mouse Anti-KIF3B Recombinant Antibody (8H4)
SKU: CBMAB-K0885-LY
Rating: 5 (1 reviews)

See all KIF3B antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

8H4

Application

ELISA, WB

Immunogen

KIF3B (NP_004789.1, 648 a.a. ~ 747 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MIRPEARYRA ENIVLLELDM PSRTTRDYEG PAIAPKVQAA LDAALQDEDE IQVDASSFES TANKKSKARP KSGRKSGSSS SSSGTPASQL YPQSRGLVPK

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

kinesin family member 3B

Introduction

The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. [provided by RefSeq, Jul 2008]

Entrez Gene ID

9371

UniProt ID

O15066

Alternative Names

Kinesin Family Member 3B; Microtubule Plus End-Directed Kinesin Motor 3B; HH0048; Kinesin-Like Protein KIF3B; KIAA0359; KLP-11; FLA8;

Function

Microtubule-based molecular motor that transport intracellular cargos, such as vesicles, organelles and protein complexes. Uses ATP hydrolysis to generate force to bind and move along the microtubule (By similarity).
Plays a role in cilia formation (PubMed:32386558).
Involved in photoreceptor integrity and opsin trafficking in rod photoreceptors (PubMed:32386558).
Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit GRIN2A into neuronal dendrites (By similarity).

Biological Process

Anterograde axonal transportManual Assertion Based On ExperimentTAS:ProtInc
Anterograde dendritic transport of neurotransmitter receptor complexISS:UniProtKB
Cilium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Determination of left/right symmetryManual Assertion Based On ExperimentTAS:ProtInc
Intraciliary transportManual Assertion Based On ExperimentIMP:UniProtKB
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Mitotic centrosome separationManual Assertion Based On ExperimentTAS:BHF-UCL
Mitotic spindle assemblyManual Assertion Based On ExperimentIMP:BHF-UCL
Mitotic spindle organizationManual Assertion Based On ExperimentTAS:BHF-UCL
Opsin transportManual Assertion Based On ExperimentIMP:UniProtKB
Plus-end-directed vesicle transport along microtubuleManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of cytokinesisIEA:Ensembl
Vesicle-mediated transportIEA:Ensembl

Cellular Location

Cytoplasm, cytoskeleton; Cell projection, dendritic spine

Involvement in disease

Retinitis pigmentosa 89 (RP89):
A form of retinitis pigmentosa, a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. RP89 is an autosomal dominant form associated with features of ciliopathy, including postaxial polydactyly, and renal and hepatic disease.

Yao, F. Z., & Kong, D. G. (2020). Identification of kinesin family member 3B (KIF3B) as a molecular target for gastric cancer. The Kaohsiung Journal of Medical Sciences, 36(7), 515-522.

Cogné, B., Latypova, X., Senaratne, L. D. S., Martin, L., Koboldt, D. C., Kellaris, G., ... & Isidor, B. (2020). Mutations in the kinesin-2 motor KIF3B cause an autosomal-dominant ciliopathy. The American Journal of Human Genetics, 106(6), 893-904.

Zhou, L., Ouyang, L., Chen, K., & Wang, X. (2019). Research progress on KIF3B and related diseases. Annals of translational medicine, 7(18).

Kravtsov, O., Hartley, C. P., Compérat, E. M., & Iczkowski, K. A. (2019). KIF3B protein expression loss correlates with metastatic ability of prostate cancer. American Journal of Clinical and Experimental Urology, 7(3), 178.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-KIF3B Recombinant Antibody (8H4)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-KIF3B Recombinant Antibody (CBLY1-087) (CAT#: CBMAB-K0884-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry