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Mouse Anti-KIF3B Recombinant Antibody (CBLY1-087) (CBMAB-K0884-LY)

This product is antibody recognizes KIF3B. The antibody CBLY1-087 immunoassay techniques such as: WB, IP, IF, ELISA.
See all KIF3B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLY1-087
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
kinesin family member 3B
Introduction
The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. [provided by RefSeq, Jul 2008]
Entrez Gene ID
9371
UniProt ID
O15066
Alternative Names
Kinesin Family Member 3B; Microtubule Plus End-Directed Kinesin Motor 3B; HH0048; Kinesin-Like Protein KIF3B; KIAA0359; KLP-11; FLA8;
Function
Microtubule-based molecular motor that transport intracellular cargos, such as vesicles, organelles and protein complexes. Uses ATP hydrolysis to generate force to bind and move along the microtubule (By similarity).
Plays a role in cilia formation (PubMed:32386558).
Involved in photoreceptor integrity and opsin trafficking in rod photoreceptors (PubMed:32386558).
Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit GRIN2A into neuronal dendrites (By similarity).
Biological Process
Anterograde axonal transportManual Assertion Based On ExperimentTAS:ProtInc
Anterograde dendritic transport of neurotransmitter receptor complexISS:UniProtKB
Cilium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Determination of left/right symmetryManual Assertion Based On ExperimentTAS:ProtInc
Intraciliary transportManual Assertion Based On ExperimentIMP:UniProtKB
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Mitotic centrosome separationManual Assertion Based On ExperimentTAS:BHF-UCL
Mitotic spindle assemblyManual Assertion Based On ExperimentIMP:BHF-UCL
Mitotic spindle organizationManual Assertion Based On ExperimentTAS:BHF-UCL
Opsin transportManual Assertion Based On ExperimentIMP:UniProtKB
Plus-end-directed vesicle transport along microtubuleManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of cytokinesisIEA:Ensembl
Vesicle-mediated transportIEA:Ensembl
Cellular Location
Cytoplasm, cytoskeleton; Cell projection, dendritic spine
Involvement in disease
Retinitis pigmentosa 89 (RP89):
A form of retinitis pigmentosa, a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. RP89 is an autosomal dominant form associated with features of ciliopathy, including postaxial polydactyly, and renal and hepatic disease.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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