KIF3B

The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. [provided by RefSeq]

Full Name

kinesin family member 3B

Function

Microtubule-based molecular motor that transport intracellular cargos, such as vesicles, organelles and protein complexes. Uses ATP hydrolysis to generate force to bind and move along the microtubule (By similarity).
Plays a role in cilia formation (PubMed:32386558).
Involved in photoreceptor integrity and opsin trafficking in rod photoreceptors (PubMed:32386558).
Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit GRIN2A into neuronal dendrites (By similarity).

Biological Process

Anterograde axonal transportManual Assertion Based On ExperimentTAS:ProtInc
Anterograde dendritic transport of neurotransmitter receptor complexISS:UniProtKB
Cilium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Determination of left/right symmetryManual Assertion Based On ExperimentTAS:ProtInc
Intraciliary transportManual Assertion Based On ExperimentIMP:UniProtKB
Microtubule-based movementManual Assertion Based On ExperimentIBA:GO_Central
Mitotic centrosome separationManual Assertion Based On ExperimentTAS:BHF-UCL
Mitotic spindle assemblyManual Assertion Based On ExperimentIMP:BHF-UCL
Mitotic spindle organizationManual Assertion Based On ExperimentTAS:BHF-UCL
Opsin transportManual Assertion Based On ExperimentIMP:UniProtKB
Plus-end-directed vesicle transport along microtubuleManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of cytokinesisIEA:Ensembl
Vesicle-mediated transportIEA:Ensembl

Cellular Location

Cytoplasm, cytoskeleton; Cell projection, dendritic spine

Involvement in disease

Retinitis pigmentosa 89 (RP89):
A form of retinitis pigmentosa, a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. RP89 is an autosomal dominant form associated with features of ciliopathy, including postaxial polydactyly, and renal and hepatic disease.