Mouse Anti-KIR3DL2 Recombinant Antibody (539304) (CBMAB-K0114-LY)

Name: Mouse Anti-KIR3DL2 Recombinant Antibody (539304)
SKU: CBMAB-K0114-LY
Rating: 5 (1 reviews)

See all KIR3DL2 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

539304

Application

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.2 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 2

Introduction

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]

Entrez Gene ID

3812

UniProt ID

P43630

Alternative Names

Killer Cell Immunoglobulin Like Receptor; Three Ig Domains And Long Cytoplasmic Tail 2; Killer Cell Immunoglobulin-Like Receptor; Three Domains; Long Cytoplasmic Tail; 2; P70 Natural Killer Cell Receptor Clone CL-5; Natural Killer-Associated Transcript 4; CD158 Antigen-Like Family Member K; MHC Class I NK Cell Receptor; P70 NK Receptor CL-5; CD158K; NKAT-4; NKAT4; Killer Cell Immunoglobulin-Like Receptor 3DL2;

Function

Receptor on natural killer (NK) cells and T cells for MHC class I molecules (PubMed:24018270, PubMed:28636952).
Upon binding of peptide-free HLA-F open conformer, negatively regulates NK and T cell effector functions (PubMed:24018270).
Acts as a receptor on astrocytes for HLA-F. Through interaction with HLA-F, may protect motor neurons from astrocyte-induced toxicity (PubMed:26928464).

Biological Process

Cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of neuron deathManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 22-340
Helical: 341-360
Cytoplasmic: 361-455

Decroos, A., Cheminant, M., Bruneau, J., Carras, S., Parinet, V., Pelletier, L., ... & Ortonne, N. (2023). KIR3DL2 may represent a novel therapeutic target in aggressive systemic peripheral T-cell lymphoma. Haematologica, 108(10), 2830.

Cheminant, M., Lhermitte, L., Bruneau, J., Sicard, H., Bonnafous, C., Touzart, A., ... & Hermine, O. (2022). KIR3DL2 contributes to the typing of acute adult T-cell leukemia and is a potential therapeutic target. Blood, The Journal of the American Society of Hematology, 140(13), 1522-1532.

Roelens, M., de Masson, A., Ram‐Wolff, C., Maki, G., Cayuela, J. M., Marie‐Cardine, A., ... & Moins‐Teisserenc, H. (2020). Revisiting the initial diagnosis and blood staging of mycosis fungoides and Sézary syndrome with the KIR3DL2 marker. British Journal of Dermatology, 182(6), 1415-1422.

Wu, Y., Yang, S., Liu, H., Luo, S., Stinchcombe, T. E., Glass, C., ... & Wei, Q. (2020). Novel genetic variants of KIR3DL2 and PVR involved in immunoregulatory interactions are associated with non-small cell lung cancer survival. American journal of cancer research, 10(6), 1770.

Bagot, M., Porcu, P., Marie-Cardine, A., Battistella, M., William, B. M., Vermeer, M., ... & Kim, Y. H. (2019). IPH4102, a first-in-class anti-KIR3DL2 monoclonal antibody, in patients with relapsed or refractory cutaneous T-cell lymphoma: an international, first-in-human, open-label, phase 1 trial. The Lancet Oncology, 20(8), 1160-1170.

Van Der Weyden, C., Bagot, M., Neeson, P., Darcy, P. K., & Prince, H. M. (2018). IPH4102, a monoclonal antibody directed against the immune receptor molecule KIR3DL2, for the treatment of cutaneous T-cell lymphoma. Expert Opinion on Investigational Drugs, 27(8), 691-697.

Hurabielle, C., Leboeuf, C., Ram‐Wolff, C., Meignin, V., Rivet, J., Vignon‐Pennamen, M. D., ... & Battistella, M. (2018). KIR3DL2 expression in patients with adult T‐cell lymphoma/leukaemia. British Journal of Dermatology, 179(1), 197-199.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-KIR3DL2 Recombinant Antibody (539304)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry