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Mouse Anti-KIR3DL2 Recombinant Antibody (539304) (CBMAB-K0114-LY)

This product is antibody recognizes KIR3DL2. The antibody 539304 immunoassay techniques such as: FC.
See all KIR3DL2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
539304
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 2
Introduction
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]
Entrez Gene ID
3812
UniProt ID
P43630
Alternative Names
Killer Cell Immunoglobulin Like Receptor; Three Ig Domains And Long Cytoplasmic Tail 2; Killer Cell Immunoglobulin-Like Receptor; Three Domains; Long Cytoplasmic Tail; 2; P70 Natural Killer Cell Receptor Clone CL-5; Natural Killer-Associated Transcript 4; CD158 Antigen-Like Family Member K; MHC Class I NK Cell Receptor; P70 NK Receptor CL-5; CD158K; NKAT-4; NKAT4; Killer Cell Immunoglobulin-Like Receptor 3DL2;
Function
Receptor on natural killer (NK) cells and T cells for MHC class I molecules (PubMed:24018270, PubMed:28636952).
Upon binding of peptide-free HLA-F open conformer, negatively regulates NK and T cell effector functions (PubMed:24018270).
Acts as a receptor on astrocytes for HLA-F. Through interaction with HLA-F, may protect motor neurons from astrocyte-induced toxicity (PubMed:26928464).
Biological Process
Cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of neuron deathManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 22-340
Helical: 341-360
Cytoplasmic: 361-455

Decroos, A., Cheminant, M., Bruneau, J., Carras, S., Parinet, V., Pelletier, L., ... & Ortonne, N. (2023). KIR3DL2 may represent a novel therapeutic target in aggressive systemic peripheral T-cell lymphoma. Haematologica, 108(10), 2830.

Cheminant, M., Lhermitte, L., Bruneau, J., Sicard, H., Bonnafous, C., Touzart, A., ... & Hermine, O. (2022). KIR3DL2 contributes to the typing of acute adult T-cell leukemia and is a potential therapeutic target. Blood, The Journal of the American Society of Hematology, 140(13), 1522-1532.

Roelens, M., de Masson, A., Ram‐Wolff, C., Maki, G., Cayuela, J. M., Marie‐Cardine, A., ... & Moins‐Teisserenc, H. (2020). Revisiting the initial diagnosis and blood staging of mycosis fungoides and Sézary syndrome with the KIR3DL2 marker. British Journal of Dermatology, 182(6), 1415-1422.

Wu, Y., Yang, S., Liu, H., Luo, S., Stinchcombe, T. E., Glass, C., ... & Wei, Q. (2020). Novel genetic variants of KIR3DL2 and PVR involved in immunoregulatory interactions are associated with non-small cell lung cancer survival. American journal of cancer research, 10(6), 1770.

Bagot, M., Porcu, P., Marie-Cardine, A., Battistella, M., William, B. M., Vermeer, M., ... & Kim, Y. H. (2019). IPH4102, a first-in-class anti-KIR3DL2 monoclonal antibody, in patients with relapsed or refractory cutaneous T-cell lymphoma: an international, first-in-human, open-label, phase 1 trial. The Lancet Oncology, 20(8), 1160-1170.

Van Der Weyden, C., Bagot, M., Neeson, P., Darcy, P. K., & Prince, H. M. (2018). IPH4102, a monoclonal antibody directed against the immune receptor molecule KIR3DL2, for the treatment of cutaneous T-cell lymphoma. Expert Opinion on Investigational Drugs, 27(8), 691-697.

Hurabielle, C., Leboeuf, C., Ram‐Wolff, C., Meignin, V., Rivet, J., Vignon‐Pennamen, M. D., ... & Battistella, M. (2018). KIR3DL2 expression in patients with adult T‐cell lymphoma/leukaemia. British Journal of Dermatology, 179(1), 197-199.

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For research use only. Not intended for any clinical use.

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