Human Recombinant KIR3DL2 protein, ECD, His Tag (V2LY-0526-LY5174)

Name: Human Recombinant KIR3DL2 protein, ECD, His Tag
SKU: V2LY-0526-LY5174
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant KIR3DL2 protein, ECD, His Tag consist of Amino Acid: 22-340 and predicts a molecular mass of 36.43 kDa.

Molecule Mass

36.43 kDa

Protein Domain

ECD

Verified

HPLC

Sequence

Amino Acid: 22-340

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 2

Function

Receptor on natural killer (NK) cells and T cells for MHC class I molecules (PubMed:24018270, PubMed:28636952).
Upon binding of peptide-free HLA-F open conformer, negatively regulates NK and T cell effector functions (PubMed:24018270).
Acts as a receptor on astrocytes for HLA-F. Through interaction with HLA-F, may protect motor neurons from astrocyte-induced toxicity (PubMed:26928464).

Biological Process

Cellular defense responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of neuron deathManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 22-340
Helical: 341-360
Cytoplasmic: 361-455

Decroos, A., Cheminant, M., Bruneau, J., Carras, S., Parinet, V., Pelletier, L., ... & Ortonne, N. (2023). KIR3DL2 may represent a novel therapeutic target in aggressive systemic peripheral T-cell lymphoma. Haematologica, 108(10), 2830.

Cheminant, M., Lhermitte, L., Bruneau, J., Sicard, H., Bonnafous, C., Touzart, A., ... & Hermine, O. (2022). KIR3DL2 contributes to the typing of acute adult T-cell leukemia and is a potential therapeutic target. Blood, The Journal of the American Society of Hematology, 140(13), 1522-1532.

Roelens, M., de Masson, A., Ram‐Wolff, C., Maki, G., Cayuela, J. M., Marie‐Cardine, A., ... & Moins‐Teisserenc, H. (2020). Revisiting the initial diagnosis and blood staging of mycosis fungoides and Sézary syndrome with the KIR3DL2 marker. British Journal of Dermatology, 182(6), 1415-1422.

Wu, Y., Yang, S., Liu, H., Luo, S., Stinchcombe, T. E., Glass, C., ... & Wei, Q. (2020). Novel genetic variants of KIR3DL2 and PVR involved in immunoregulatory interactions are associated with non-small cell lung cancer survival. American journal of cancer research, 10(6), 1770.

Bagot, M., Porcu, P., Marie-Cardine, A., Battistella, M., William, B. M., Vermeer, M., ... & Kim, Y. H. (2019). IPH4102, a first-in-class anti-KIR3DL2 monoclonal antibody, in patients with relapsed or refractory cutaneous T-cell lymphoma: an international, first-in-human, open-label, phase 1 trial. The Lancet Oncology, 20(8), 1160-1170.

Van Der Weyden, C., Bagot, M., Neeson, P., Darcy, P. K., & Prince, H. M. (2018). IPH4102, a monoclonal antibody directed against the immune receptor molecule KIR3DL2, for the treatment of cutaneous T-cell lymphoma. Expert Opinion on Investigational Drugs, 27(8), 691-697.

Hurabielle, C., Leboeuf, C., Ram‐Wolff, C., Meignin, V., Rivet, J., Vignon‐Pennamen, M. D., ... & Battistella, M. (2018). KIR3DL2 expression in patients with adult T‐cell lymphoma/leukaemia. British Journal of Dermatology, 179(1), 197-199.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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