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Mouse Anti-KIRREL3 Recombinant Antibody (3A12) (CBMAB-K0952-LY)

This product is antibody recognizes KIRREL3. The antibody 3A12 immunoassay techniques such as: ELISA, WB.
See all KIRREL3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3A12
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
KIRREL3 (NP_115920.1, 679 a.a. ~ 778 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: YSTLSGQGRL YDYGQRFVLG MGSSSIELCE REFQRGSLSD SSSFLDTQCD SSVSSSGKQD GYVQFDKASK ASASSSHHSQ SSSQNSDPSR PLQRRMQTHV
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
kin of IRRE like 3 (Drosophila)
Introduction
The protein encoded by this gene is a member of the nephrin-like protein family. These proteins are expressed in fetal and adult brain, and also in podocytes of kidney glomeruli. The cytoplasmic domains of these proteins interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. The protein encoded by this gene is a synaptic cell adhesion molecule with multiple extracellular immunoglobulin-like domains and a cytoplasmic PDZ domain-binding motif. Mutations in this gene are associated with several neurological and cognitive disorders. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]
Entrez Gene ID
UniProt ID
Alternative Names
Kirre Like Nephrin Family Adhesion Molecule 3; Kin Of Irregular Chiasm-Like Protein 3; Nephrin-Like Protein 2; NEPH2; Kin Of IRRE Like 3 (Drosophila); Kin Of IRRE-Like Protein 3; Kin Of IRRE Like 3;
Function
Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells.
Biological Process
Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Glomerulus morphogenesisIEA:Ensembl
HemopoiesisISS:UniProtKB
Hippocampus developmentISS:UniProtKB
Homophilic cell adhesion via plasma membrane adhesion moleculesISS:UniProtKB
Inter-male aggressive behaviorIEA:Ensembl
Neuron migrationIEA:Ensembl
Neuron projection morphogenesisIEA:Ensembl
Principal sensory nucleus of trigeminal nerve developmentIEA:Ensembl
Synapse assemblyISS:UniProtKB
Cellular Location
Cell membrane
Processed kin of IRRE-like protein 3: Secreted
Involvement in disease
A chromosomal aberration involving KIRREL3 and CDH15 is found in a patient with severe mental retardation and dysmorphic facial features. Translocation t(11;16)(q24.2;q24).
Topology
Extracellular: 22-535
Helical: 536-556
Cytoplasmic: 557-778
PTM
Undergoes proteolysis by a metalloprotease and gives rise to a soluble form.

Querzani, A., Sirchia, F., Rustioni, G., Rossi, A., Orsini, A., Marseglia, G. L., ... & Foiadelli, T. (2023). KIRREL3-related disorders: a case report confirming the radiological features and expanding the clinical spectrum to a less severe phenotype. Italian Journal of Pediatrics, 49(1), 99.

Traenkner, D., Shennib, O., Johnson, A., Weinbrom, A., Taylor, M. R., & Williams, M. E. (2023). Modular Splicing is Linked to Evolution in the Synapse-Specificity Molecule Kirrel3. eNeuro.

Yang, B., Zhang, X., Zhou, H., Zhang, X., Yang, W., Lu, J., ... & Tian, F. (2022). Preliminary study on the role and mechanism of KIRREL3 in the development of esophageal squamous cell carcinoma. Pathology-Research and Practice, 237, 154025.

Ciaccio, C., Leonardi, E., Polli, R., Murgia, A., D'Arrigo, S., Granocchio, E., ... & Esposito, S. (2021). A missense de novo variant in the CASK-interactor KIRREL3 gene leading to neurodevelopmental disorder with mild cerebellar hypoplasia. Neuropediatrics, 52(06), 484-488.

Taylor, M. R., Martin, E. A., Sinnen, B., Trilokekar, R., Ranza, E., Antonarakis, S. E., & Williams, M. E. (2020). Kirrel3-mediated synapse formation is attenuated by disease-associated missense variants. Journal of Neuroscience, 40(28), 5376-5388.

Völker, L. A., Maar, B. A., Pulido Guevara, B. A., Bilkei‐Gorzo, A., Zimmer, A., Brönneke, H., ... & Hoehne, M. (2018). Neph2/Kirrel3 regulates sensory input, motor coordination, and home‐cage activity in rodents. Genes, Brain and Behavior, 17(8), e12516.

Hisaoka, T., Komori, T., Kitamura, T., & Morikawa, Y. (2018). Abnormal behaviours relevant to neurodevelopmental disorders in Kirrel3-knockout mice. Scientific Reports, 8(1), 1408.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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