Rabbit Anti-KIRREL3 Recombinant Antibody (CBLY1-101) (CBMAB-K0951-LY)

Name: Rabbit Anti-KIRREL3 Recombinant Antibody (CBLY1-101)
SKU: CBMAB-K0951-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBLY1-101

Application

Specificity

Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

kin of IRRE like 3 (Drosophila)

Introduction

The protein encoded by this gene is a member of the nephrin-like protein family. These proteins are expressed in fetal and adult brain, and also in podocytes of kidney glomeruli. The cytoplasmic domains of these proteins interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. The protein encoded by this gene is a synaptic cell adhesion molecule with multiple extracellular immunoglobulin-like domains and a cytoplasmic PDZ domain-binding motif. Mutations in this gene are associated with several neurological and cognitive disorders. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]

Entrez Gene ID

Human	84623
Rat	315546

UniProt ID

Human	Q8IZU9
Rat	E9PTD7

Function

Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells.

Biological Process

Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Glomerulus morphogenesisIEA:Ensembl
HemopoiesisISS:UniProtKB
Hippocampus developmentISS:UniProtKB
Homophilic cell adhesion via plasma membrane adhesion moleculesISS:UniProtKB
Inter-male aggressive behaviorIEA:Ensembl
Neuron migrationIEA:Ensembl
Neuron projection morphogenesisIEA:Ensembl
Principal sensory nucleus of trigeminal nerve developmentIEA:Ensembl
Synapse assemblyISS:UniProtKB

Cellular Location

Cell membrane
Processed kin of IRRE-like protein 3: Secreted

Involvement in disease

A chromosomal aberration involving KIRREL3 and CDH15 is found in a patient with severe mental retardation and dysmorphic facial features. Translocation t(11;16)(q24.2;q24).

Topology

Extracellular: 22-535
Helical: 536-556
Cytoplasmic: 557-778

PTM

Undergoes proteolysis by a metalloprotease and gives rise to a soluble form.

Querzani, A., Sirchia, F., Rustioni, G., Rossi, A., Orsini, A., Marseglia, G. L., ... & Foiadelli, T. (2023). KIRREL3-related disorders: a case report confirming the radiological features and expanding the clinical spectrum to a less severe phenotype. Italian Journal of Pediatrics, 49(1), 99.

Traenkner, D., Shennib, O., Johnson, A., Weinbrom, A., Taylor, M. R., & Williams, M. E. (2023). Modular Splicing is Linked to Evolution in the Synapse-Specificity Molecule Kirrel3. eNeuro.

Yang, B., Zhang, X., Zhou, H., Zhang, X., Yang, W., Lu, J., ... & Tian, F. (2022). Preliminary study on the role and mechanism of KIRREL3 in the development of esophageal squamous cell carcinoma. Pathology-Research and Practice, 237, 154025.

Ciaccio, C., Leonardi, E., Polli, R., Murgia, A., D'Arrigo, S., Granocchio, E., ... & Esposito, S. (2021). A missense de novo variant in the CASK-interactor KIRREL3 gene leading to neurodevelopmental disorder with mild cerebellar hypoplasia. Neuropediatrics, 52(06), 484-488.

Taylor, M. R., Martin, E. A., Sinnen, B., Trilokekar, R., Ranza, E., Antonarakis, S. E., & Williams, M. E. (2020). Kirrel3-mediated synapse formation is attenuated by disease-associated missense variants. Journal of Neuroscience, 40(28), 5376-5388.

Völker, L. A., Maar, B. A., Pulido Guevara, B. A., Bilkei‐Gorzo, A., Zimmer, A., Brönneke, H., ... & Hoehne, M. (2018). Neph2/Kirrel3 regulates sensory input, motor coordination, and home‐cage activity in rodents. Genes, Brain and Behavior, 17(8), e12516.

Hisaoka, T., Komori, T., Kitamura, T., & Morikawa, Y. (2018). Abnormal behaviours relevant to neurodevelopmental disorders in Kirrel3-knockout mice. Scientific Reports, 8(1), 1408.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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